[Expression of adhesion molecules LFA-1 and L-selectin on PMN and level of soluble sE-selectin and sL-selectin in the serum of patients with small cell lung cancer].
[Expression of adhesion molecules LFA-1 and L-selectin on PMN and level of soluble sE-selectin and sL-selectin in the serum of patients with small cell lung cancer].
复制标题
黏附分子LFA-1、L-选择素在PMN上的表达及小细胞肺癌患者血清中可溶性sE-选择素、sL-选择素的水平
DOI：
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发表时间：
2002
影响因子：
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通讯作者：
E. Chyczewska
中科院分区：
文献类型：
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作者：
A. Izycka;E. Jabłońska;T. Izycki;E. Chyczewska
本研究的目的是评估16例小细胞肺癌（SCLC）患者治疗前外周血PMN上粘附分子LFA-1和L-选择素的表达，以及血清中可溶性sE-选择素和sL-选择素的水平。我们观察到，与健康人相比，PMN 上 LFA-1 和 L-选择素的表达显着更高，SCLC 患者血清中 sE 选择素和 sL 选择素的水平更高。 PMN 上粘附分子表达的增加可导致肿瘤细胞损伤，也可能是产生新癌症部位的原因之一。
The aim of this study was to estimate expression of adhesion molecules LFA-1 and L-selectin on PMN of peripheral blood, and level of soluble sE-selectin and sL-selectin in the serum of 16 patients with small cell lung cancer (SCLC) before treatment. We observed significantly higher expression of LFA-1 and L-selectin on PMN in comparison to healthy persons and higher level sE selectin and sL selectin in the serum of SCLC patients. Increasing of adhesion molecules expression on PMN can lead to damage of neoplasmatic cells and may be one of the reasons for create a new cancer sites as well.