Kynurenines in the regulation of behavior in insects.
Kynurenines in the regulation of behavior in insects.
复制标题
犬尿氨酸在昆虫行为调节中的作用。
DOI：
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发表时间：
1991
影响因子：
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通讯作者：
E. Savvateeva
中科院分区：
文献类型：
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作者：
E. Savvateeva
在证明犬尿氨酸作为 NMDA 受体的内源性调节剂的可能作用后，犬尿氨酸的作用位点和机制引起了广泛的关注，NMDA 受体参与调节中枢神经系统的基本功能和疾病，例如多种物种的学习、记忆、缺血、癫痫和一些退行性疾病（Stone 和 Connick，1985）。由于遗传学为神经科学提供了强大的工具，对色氨酸代谢的犬尿氨酸途径（KPTM）的突变剖析似乎在阐明犬尿氨酸的机制和行为表现方面取得了丰硕的成果。值得注意的是，生化遗传学可以追溯到 1941 年，当时 Beadle 和 Tatum 使用果蝇的眼睛颜色突变体通过 KPTM 证明了反应的确切顺序。
The site and the mechanism of kynurenines effects have drawn much attention after the demonstration of their possible role as endogenous modulators of the NMDA receptor, which are involved in the mediation of basic functions and disorders in the central nervous system, such as learning, memory, ischemia, epilepsy and some degenerative diseases in a variety of species (Stone and Connick, 1985). Since genetics lend a powerful tool to the neurosciences, the mutational dissection of the kynurenine pathway of tryptophan metabolism (KPTM) seems to be fruitful in the elucidation of the mechanisms and behavioral manifestations of the kynurenines. It is noteworthy that biochemical genetics date back to 1941, when the eye-color mutants of Drosophila were used by Beadle and Tatum to demonstrate the exact sequence of reactions via the KPTM.