The Intestinal Microbiome, Dietary Habits, and Physical and Psychological Resilience in Postpartum Women
The Intestinal Microbiome, Dietary Habits, and Physical and Psychological Resilience in Postpartum Women
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DOI：
10.1101/2022.09.07.506896
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发表时间：
2022-09
期刊：
影响因子：
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通讯作者：
Michiko Matsunaga;Mariko Takeuchi;S. Watanabe;Aya K Takeda;T. Kikusui;K. Mogi;M. Nagasawa;K. Hagihara;Masako Myowa
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文献类型：
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作者：
Michiko Matsunaga;Mariko Takeuchi;S. Watanabe;Aya K Takeda;T. Kikusui;K. Mogi;M. Nagasawa;K. Hagihara;Masako Myowa
患有精神疾病的产后妇女人数稳步增加，尤其是在COVID-19大流行的情况下。迫切需要确定有助于产后妇女恢复力的因素，以减少身体和心理功能不良的风险。研究已经将肠道微生物群的变化与临床样本中的抑郁症联系起来，但对日本人口中产后妇女的影响尚不清楚。我们进行了两项研究，以检查非临床产后日本妇女的肠道微生物群，身体状况和心理状态之间的联系。我们的研究结果表明，降低毛螺菌和微生物组的α多样性与高心理健康风险有关（即，父母压力和/或抑郁症）。心理弹性和身体状况与布劳特氏菌属，梭菌属，Eggerthella的相对丰度。这项研究有助于进一步了解肠-脑轴机制，并支持干预措施，以提高产后妇女的韧性的建议。
The population of postpartum women suffering from mental illness is increasing steadily, particularly under conditions of the COVID-19 pandemic. Identifying factors that contribute to resilience in postpartum women is urgently needed to decrease risks of poor physical and psychological functioning. Studies have linked variations in the intestinal microbiota to depression in clinical samples, but the impacts in postpartum women in a Japanese population are unknown. We conducted two studies to examine the links between intestinal microbiota, physical condition, and psychological state in nonclinical, postpartum Japanese women. Our results show that decreasing Lachnospira and alpha diversity of microbiome is related to high mental health risk (i.e., parenting stress and/or depression). Psychological resilience and physical conditions were associated with relative abundances of genera Blautia, Clostridium, Eggerthella. This study contributes to further understanding of the gut-brain axis mechanisms and supports proposals for interventions to enhance resilience in postpartum women.