Modeling human development and disease in Xenopus. Preface.
Modeling human development and disease in Xenopus. Preface.
复制标题
在非洲爪蟾中模拟人类发育和疾病。
DOI：
10.1016/j.ydbio.2015.11.019
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发表时间：
2015
影响因子：
2.7
通讯作者：
Zorn,AaronM
中科院分区：
文献类型：
--
作者：
LaBonne,Carole;Zorn,AaronM
非洲爪蟾一直是一个强大的和重要的动物模型，研究在发育和细胞生物学的基本问题，由于该系统的独特的实验优势。毫不奇怪，对非洲爪蟾的研究也越来越多地为我们了解人类健康和疾病做出重要贡献。非洲爪蟾胚胎发育迅速，作为实验平台具有广泛的优势。重要的是，非洲爪蟾还弥合了更昂贵和更不容易处理的哺乳动物模型与进化上更遥远的斑马鱼模型之间的差距，因此它具有独特的地位，可以告知与人类健康相关的保守生物过程。这期特刊以评论和原创研究论文的形式重点介绍了这些研究领域。这是生物医学研究中令人兴奋和变革的时刻。蛋白质组学、基因组学和基因组编辑的快速发展，使人们能够以前所未有的规模分析发育、细胞功能和疾病。虽然非洲爪蟾经常是需要生物化学方法和机械深度的脊椎动物研究的首选模型，但它也非常适合系统级分析，功能基因组学和人类疾病建模。支持这一模式工作的重要资源的开发，包括在马萨诸塞州伍兹霍尔建立国家爪蟾资源（NXR），促进了这类研究（以补充欧洲非洲爪蟾资源中心和日本国家生物资源项目），非洲爪蟾和热带爪蟾的基因组注释越来越好，以及继续开发在线系统资源和生物信息学数据库Xenbase（http：//xenbase. org），包括增加了宝贵的转录组和蛋白质组数据集。值得注意的是，在本期中，格兰特等人报告了一种重要的新资源的建立，
Xenopus has long been a powerful and important animal model for investigating fundamental questions in developmental and cell biology due to the unique experimental advantages of this system. Not surprisingly, studies in Xenopus are increasingly also making important contributions to our understanding of human health and disease. Xenopus embryos develop rapidly and have broad strengths as an experimental platform. Importantly, Xenopus also bridges the gap between more costly and less tractable mammalian models and the evolutionarily more distant zebrafish model, and as such it is uniquely positioned to inform conserved biological processes relevant to human health. This Special Issue highlights a number of these research areas with reviews and original research papers.This is an exciting and transformative time in biomedical research. Rapid advances in proteomics, genomics and genome editing are enabling analyses of development, cellular function and disease on an unprecedented scale. While Xenopus has frequently been the model of choice for vertebrate studies requiring biochemical approaches and mechanistic depth, it is also ideally suited to systems-level analysis, functional genomics and human disease modeling. Such studies have been facilitated by the development of important resources supporting work in this model, including the establishment of the National Xenopus Resource (NXR) in Woods Hole, MA (to complement the European Xenopus Resource Center and the National BioResource Project of Japan), the increasingly well annotated genomes for both Xenopus laevis and Xenopus tropicalis, and the continued development of the online system resource and bioinformatics database Xenbase (http://xenbase. org), including the addition of invaluable transcriptome and proteomic datasets. Notably, in this issue Grant et al. report the establishment of an important new resource, the