Estrogen signaling in lung cancer: an opportunity for novel therapy.
Estrogen signaling in lung cancer: an opportunity for novel therapy.
复制标题
肺癌中的雌激素信号传导：新型治疗的机会。
DOI：
10.3390/cancers4040969
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发表时间：
2012-09-25
期刊：
影响因子：
5.2
通讯作者：
Eaton KD
中科院分区：
文献类型：
--
作者：
Baik CS;Eaton KD
肺癌是美国癌症死亡的主要原因，也是一项重大的公共卫生负担。流行病学数据表明，女性肺癌可能具有与男性不同的生物学特征，女性肺癌患者中从不吸烟的比例较高就证明了这一点。新数据表明，雌激素和黄体酮等女性激素在肺癌发生中发挥着重要作用。据报道，雌激素和孕激素受体在肺癌细胞系以及患者来源的肿瘤中表达。激素相关的危险因素（例如激素替代疗法）与肺癌发生有关，一些临床前研究表明抗雌激素疗法在肺癌中具有活性。在这篇综述中，我们总结了生殖激素在肺癌中的作用的新证据以及对肺癌治疗的影响。
Lung cancer is the leading cause of cancer death in U.S. and represents a major public health burden. Epidemiologic data have suggested that lung cancer in women may possess different biological characteristics compared to men, as evidenced by a higher proportion of never-smokers among women with lung cancer. Emerging data indicate that female hormones such as estrogen and progesterone play a significant role in lung carcinogenesis. It has been reported that estrogen and progesterone receptors are expressed in lung cancer cell lines as well as in patient-derived tumors. Hormone related risk factors such as hormone replacement therapy have been implicated in lung carcinogenesis and several preclinical studies show activity of anti-estrogen therapy in lung cancer. In this review, we summarize the emerging evidence for the role of reproductive hormones in lung cancer and implications for lung cancer therapy.