Clinical Impact of Paravalvular Leaks on Biomarkers and Survival After Transcatheter Aortic Valve Implantation
Clinical Impact of Paravalvular Leaks on Biomarkers and Survival After Transcatheter Aortic Valve Implantation
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DOI：
10.1002/ccd.25295
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发表时间：
2015-02-15
影响因子：
2.3
通讯作者：
Schaefer, Ulrich
中科院分区：
文献类型：
--
作者：
Schewel, Dimitry;Frerker, Christian;Schaefer, Ulrich
BackgroundThere是积累的证据表明，高达20%的植入装置后，TAVI与一个显着程度的瓣周漏，这似乎是与一个负面的临床outcome.MethodsA共355例严重主动脉瓣狭窄（AVS）进行了TAVI治疗（Corevalve n=222，Edwards Sapien n=133）。生存率，NT-proBNP和PVL的等级进行了量化到12个月后implantation.ResultsTechnical成功率为97.8%。30天死亡率为9.6%。仅在少数病例（5%）中观察到术后跨瓣主动脉瓣返流，而PVL经常观察到（等级：
BackgroundThere is accumulating evidence that up to 20% of the implanted devices after TAVI are associated with a significant degree of paravalvular leaks, which appear to be associated with a negative clinical outcome.MethodsA total of 355 patients with severe aortic valvular stenosis (AVS) were treated by TAVI (Corevalve n=222, Edwards Sapien n=133). Survival, NT-proBNP and the grade of PVL were quantified up to 12 months after implantation.ResultsTechnical success rate was 97.8%. Thirty-day mortality was 9.6%. Post-procedural transvalvular aortic regurgitation was seen only in a minority of cases (5%), whereas PVL were frequently observed (grade: