Metabolic changes in the normal ageing brain: Consistent findings from short and long echo time proton spectroscopy
Metabolic changes in the normal ageing brain: Consistent findings from short and long echo time proton spectroscopy
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DOI：
10.1016/j.ejrad.2007.08.038
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发表时间：
2008-11-01
影响因子：
3.3
通讯作者：
Moser, E.
中科院分区：
文献类型：
--
作者：
Gruber, S.;Pinker, K.;Moser, E.
目的：63个健康的亚红，以评估依赖于年龄的脑代谢产物，使用短和长回波时间spectroscopy在不同的大脑regions.Material和方法：年轻和老年人进行了测量与长回波时间（TE = 135 ms）3D-MR光谱成像（MRSI）（10名）和超短回波（TE = 11 ms）时间2D-MRSI（7名）。此外，结果从单体素H-1光谱结果：3D-MRSI显示老年组额叶NAA/Cr比值降低（-22%; p < 0.01）、顶叶（-28%; p < 0.01）和半卵圆（-9%; p < 0.01）。Cho/Cr在半卵圆（+35%; p < 0.01）和n.在老年组中，豆状肌（+42%; p < 0.01）。与年轻组相比，老年组中除丘脑外，所有测量区域的NAA/Cho均降低（从-21%至-49%：p < 0.01）。2D-MRSI显示总NAA减少（每十年-3.1%; p < 0.01）和NAA/Cr（每十年-3.8% p < 0.01），总Cho增加（每十年+3.6%; p < 0.01）和Cho/Cr（每十年+4.6%; p < 0.01）和总肌肌醇增加在半卵圆WM中，mI（每十年+4.7%; p < 0.01）和mI/Cr（每十年+5.4%; p < 0.01）以及NAA/Cho降低（每十年-8%; p < 0.01）。单体素波谱分析结果显示，额叶（每10年-13%，p < 0.01）和颞叶（每10年-7.4%，p < 0.01）的NAA/Cho呈显著负相关，额叶的总Cr增加（每10年10%，p < 0.01）。从单体素测量的其他结果并不显着，但趋势是可比的，从多体素spectroscopic.Conclusion：与长回波时间和短回波时间1H-MRS测量的MRI相关的变化是可比的，因此，不能引起不同的T2弛豫时间在年轻和老年人的主题，如前所述。(C)2007爱思唯尔爱尔兰有限公司保留所有权利。
Objectives: Sixty three healthy sub red to assess dependence of brain metabolites on age using short- and long echo time spectroscopy in different brain regions.Material and methods: Younger and elderly humans were measured with long echo time (TE = 135 ms) 3D-MR-spectroscopic imaging (MRSI) (10 subjects) and with ultra-short echo (TE = 11 ms) time 2D-MRSI (7 subjects). In addition, results from single voxel H-1-spectroscopy (TE = 20 ms) of two cohorts of 46 healthy subjects were retrospectively correlated with age.Results: 3D-MR SI revealed reduced NAA/Cr in the older group in the frontal lobe (-22%; p < 0.01), parietal lobe (-28%; p < 0.01) and semiovale (-9%; p < 0.01) compared to the younger group. Cho/Cr was elevated in the semiovale (+35%; p < 0.01) and in the n. lentiformis (+42%; p < 0.01) in the older group. NAA/Cho was reduced in all regions measured, except the thalamus, in the older group compared to the younger group (from -21 to -49%: p < 0.01). 2D-MRSI revealed decreased total NAA (-3.1% per decade; p < 0.01) and NAA/Cr (-3.8% per decades p < 0.01), increased total Cho(+3.6% per decade; p < 0.01) and Cho/Cr (+4.6% per decade; p < 0.01) and increased total myo-Inositol (mI, +4.7% per decade; p < 0.01) and mI/Cr (+5.4% per decade; p < 0.01) and decreased NAA/Cho (-8% per decade; p < 0.01) in semiovale WM. Results from single voxel spectroscopy revealed a significantly negative correlation of NAA/Cho in frontal (-13% per decade; p < 0.01) and in temporal lobe (-7.4% per decade; p < 0.01) as well as increased total Cr (10% per decade; p < 0.01) in frontal lobe. Other results from single voxel measurements were not significant, but trends were comparable to that from multivoxel spectroscopy.Conclusion: Age-related changes measured with long echo time and short echo time 1H-MRS were comparable and cannot, therefore, be caused by different T2 relaxation times in young and old subjects, as suggested previously. (C) 2007 Elsevier Ireland Ltd. All rights reserved.