Animal Models of Alzheimer Disease
Animal Models of Alzheimer Disease
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DOI：
10.1101/cshperspect.a006320
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发表时间：
2012-11-01
影响因子：
5.4
通讯作者：
Green, Kim N.
中科院分区：
文献类型：
--
作者：
LaFerla, Frank M.;Green, Kim N.
通过研究转基因动物，对阿尔茨海默病和相关痴呆症相关基因的功能有了重要的了解。虽然没有一个现有的模型完全再现了这种潜伏的人类疾病的完整谱，但阿尔茨海默病病理学和疾病过程的关键方面可以通过实验重现。转基因动物模型有助于我们进一步了解疾病的潜在机制，并已被证明在潜在治疗干预措施的临床前评估中非常宝贵。继续改进和发展以产生下一代动物模型将有助于成功地在临床前研究和人类临床试验之间产生更大的翻译一致性，并最终导致将新疗法引入临床实践。
Significant insights into the function of genes associated with Alzheimer disease and related dementias have occurred through studying genetically modified animals. Although none of the existing models fully reproduces the complete spectrum of this insidious human disease, critical aspects of Alzheimer pathology and disease processes can be experimentally recapitulated. Genetically modified animal models have helped advance our understanding of the underlying mechanisms of disease and have proven to be invaluable in the preclinical evaluation of potential therapeutic interventions. Continuing refinement and evolution to yield the next generation of animal models will facilitate successes in producing greater translational concordance between preclinical studies and human clinical trials and eventually lead to the introduction of novel therapies into clinical practice.