Cell-to-cell signaling and Pseudomonas aeruginosa infections.
Cell-to-cell signaling and Pseudomonas aeruginosa infections.
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DOI：
10.3201/eid0404.980405
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发表时间：
1998-10
影响因子：
11.8
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中科院分区：
文献类型：
--
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铜绿假单胞菌是导致严重医院感染、免疫功能低下者中危及生命的感染和囊性纤维化患者中慢性感染的细菌。细菌的毒力取决于大量的细胞相关和细胞外因子。细胞间信号系统控制表达，并允许许多细胞外毒力因子的协调的、细胞密度依赖性的产生。我们讨论了细胞间信号传导在铜绿假单胞菌感染发病机制中的可能作用，并提出了在开发新的治疗方法时靶向细胞间信号传导系统的基本原理。
Pseudomonas aeruginosa is a bacterium responsible for severe nosocomial infections, life-threatening infections in immunocompromised persons, and chronic infections in cystic fibrosis patients. The bacterium's virulence depends on a large number of cell-associated and extracellular factors. Cell-to-cell signaling systems control the expression and allow a coordinated, cell-density-dependent production of many extracellular virulence factors. We discuss the possible role of cell-to-cell signaling in the pathogenesis of P. aeruginosa infections and present a rationale for targeting cell-to-cell signaling systems in the development of new therapeutic approaches.