Consensus on the pathological definition and classification of poorly cohesive gastric carcinoma
Consensus on the pathological definition and classification of poorly cohesive gastric carcinoma
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DOI：
10.1007/s10120-018-0868-0
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发表时间：
2019-01-01
期刊：
影响因子：
7.4
通讯作者：
de Manzoni, Giovanni
中科院分区：
文献类型：
--
作者：
Mariette, C.;Carneiro, F.;de Manzoni, Giovanni
背景和目的胃癌（GC）的临床病理学特征正在发生变化，尤其是在西方，远端、直肠型肿瘤的发病率下降，而劳伦弥漫型或WHO低粘性（PC）肿瘤（包括印戒细胞（SRC）组织学类型）的比例相应增加。为了准确地评估这些GC亚型的行为和预后，病理学定义的标准化是need.MethodsA多学科的专家小组属于欧洲分会的国际胃癌协会（IGCA）确定了11个主题的病理分类用于PC和SRC GC。2017年3月在维罗纳举行的专门研讨会上对这些主题进行了辩论。然后，通过一个德尔菲法，共识声明为每个主题elaborated.ResultsA共识，需要根据最新版的WHO分类胃癌，目前是WHO 2010年。此外，为了标准化SRC癌的定义，提出了只有具有超过90%的具有印戒细胞形态的低粘附细胞的WHO PC癌必须被分类为SRC癌的建议。所有其他PC非SRC类型必须进一步细分为具有SRC成分的PC癌（10% SRC）和未另行说明的PC癌（
Background and aimsClinicopathological characteristics of gastric cancer (GC) are changing, especially in the West with a decreasing incidence of distal, intestinal-type tumours and the corresponding increasing proportion of tumours with Lauren diffuse or WHO poorly cohesive (PC) including signet ring cell (SRC) histology. To accurately assess the behaviour and the prognosis of these GC subtypes, the standardization of pathological definitions is needed.MethodsA multidisciplinary expert team belonging to the European Chapter of International Gastric Cancer Association (IGCA) identified 11 topics on pathological classifications used for PC and SRC GC. The topics were debated during a dedicated Workshop held in Verona in March 2017. Then, through a Delphi method, consensus statements for each topic were elaborated.ResultsA consensus was reached on the need to classify gastric carcinoma according to the most recent edition of the WHO classification which is currently WHO 2010. Moreover, to standardize the definition of SRC carcinomas, the proposal that only WHO PC carcinomas with more than 90% poorly cohesive cells having signet ring cell morphology have to be classified as SRC carcinomas was made. All other PC non-SRC types have to be further subdivided into PC carcinomas with SRC component (10% SRCs) and PC carcinomas not otherwise specified (