MORPHOMETRY FOR EARLY MONITORING OF TREATMENT RESPONSE IN RHEUMATOID ARTHRITIS.
MORPHOMETRY FOR EARLY MONITORING OF TREATMENT RESPONSE IN RHEUMATOID ARTHRITIS.
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用于早期监测类风湿关节炎治疗反应的形态学。
DOI：
10.1109/isbi.2013.6556427
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
Chaudhari,AbhijitJ
中科院分区：
文献类型：
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作者：
Joshi,AnandA;Leahy,RichardM;Badawi,RamseyD;Chaudhari,AbhijitJ
最近出现了新的积极治疗方案，可用于治疗炎性关节炎(IA)，特别是类风湿性关节炎。这些治疗方法不仅可以控制关节的破坏，还可以帮助侵蚀骨部位的新骨形成。将这些治疗的无应答者与应答者分开是至关重要的，众所周知，它可以减少疾病负担、毒性、副作用和总成本。手腕的骨骼是IA的早期靶点，众所周知，对治疗的早期反应。在这篇论文中，我们开发了一种方法来量化正在接受治疗的IA患者腕骨的点状侵蚀变化。该方法采用基于三维配准的形态计量分析。我们的结果表明，所提出的方法有可能提高对骨侵蚀状态的早期微小变化的敏感性。这项研究有可能提供新的成像生物标记物，用于临床试验，评估新的关节炎药物的疗效。
New aggressive therapeutic options have recently become available to treat inflammatory arthritis (IA) and rheumatoid arthritis in particular. These treatments not only control joint destruction, they may also aid in new bone formation at sites of eroded bone. Separation of non-responders from responders to these treatments, is critical, and is known to lead to reduced disease burden, toxicity, side-effects and overall cost. The bones of the wrist are early targets of IA and are known to show response to therapy early. In this paper, we develop a method to quantify point-wise erosive changes of wrist bones in IA patients undergoing treatment. The method employs 3D registration-based morphometric analysis. Our results indicate that the proposed method has potential to improve sensitivity to small, early changes in bone erosion status. This study has potential to provide new imaging biomarkers to be used in clinical trials evaluating the efficacy of new arthritis drugs.