Pressor and non-pressor effects of sodium loading on stroke in stroke-prone spontaneously hypertensive rats
Pressor and non-pressor effects of sodium loading on stroke in stroke-prone spontaneously hypertensive rats
复制标题
钠负荷对易发生中风的自发性高血压大鼠中风的升压和非升压作用
DOI：
10.1111/j.1440-1681.2007.04746.x
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发表时间：
2008-01-01
影响因子：
2.9
通讯作者：
Su, Ding-Feng
中科院分区：
文献类型：
--
作者：
Zhang, Wei;Liu, Ai-Jun;Su, Ding-Feng
1.病因学研究表明，钠负荷增加血压和中风死亡。本研究旨在探讨钠负荷对易卒中型自发性高血压大鼠（SHRSP）脑卒中的升压和非升压作用.使用了85只雌性SHRSP。将49只5月龄SHRSP随机分为钠负荷组和非钠负荷组，记录其存活时间。将36只3月龄SHRSP随机分为两组，分别在钠负荷或正常饲料4个月后测定血压、心率和压力反射敏感性（BRS）。BRS测定后，取血测定肿瘤坏死因子（TNF）、白细胞介素（IL）-1 β、IL-6和血管紧张素（Ang）II，并取脑组织进行光镜检查. 15个月内，对照组SHRSP的死亡率为37.5%，钠负荷组为80.0%。与对照组相比，高钠负荷组大鼠血压升高，BRS降低（P < 0.001）。钠负荷组IL-1 β、IL-6和AngII水平均显著升高（P < 0.05）。钠负荷也明显增加脑动脉瘤的数量。多因素回归分析显示IL-6是与动脉瘤形成相关性最显著的因素.钠负荷增加SHRSP中风死亡率血压升高、BRS受损、炎症反应和脑动脉瘤的形成可能是脑卒中发生的重要原因。
1. Aetiological studies have shown that sodium loading increases both blood pressure and death from stroke. The present study was designed to investigate the pressor and non-pressor effects of sodium loading on stroke in stroke-prone spontaneously hypertensive rats (SHRSP).2. Eighty-five female SHRSP were used. Forty-nine SHRSP, aged 5 months, were randomly divided into two groups with or without sodium loading and their survival times were recorded. Thirty-six SHRSP, aged 3 months, were randomly divided into two groups and were instrumented to determine blood pressure, heart period and baroreflex sensitivity (BRS) after 4 months of sodium loading or normal rat chow. After determination of BRS, blood samples were collected for the measurement of tumour necrosis factor (TNF), interleukin (IL)-1 beta, IL-6 and angiotensin (Ang) II and brains were dissected for light microscopic examination.3. Over the 15 month period, the mortality of control SHRSP was 37.5%, which reached 80.0% in the sodium loading group. Compared with the control group, blood pressure was increased but BRS was significantly decreased (P < 0.001) in sodium-loaded rats. Levels of IL-1 beta, IL-6 and AngII were all significantly increased (P < 0.05) in the sodium-loaded rats. Sodium loading also markedly increased the number of cerebral aneurysms. Multivariate regression analysis showed that IL-6 was the most significant factor related to aneurysm formation.4. Sodium loading increases death from stroke in SHRSP. The increased blood pressure, impaired BRS, inflammatory reaction and the formation of cerebral aneurysms may contribute to the development of stroke.