Body mass index and lung cancer - A case-control study of subjects participating in a mass-screening program
Body mass index and lung cancer - A case-control study of subjects participating in a mass-screening program
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DOI：
10.1378/chest.128.3.1490
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发表时间：
2005-09-01
期刊：
影响因子：
9.6
通讯作者：
Sekizawa, K
中科院分区：
文献类型：
--
作者：
Kanashiki, A;Sairenchi, T;Sekizawa, K
研究目的：先前的研究报道体重指数（BMI）与肺癌风险呈负相关，这表明消瘦是肺癌的一个风险因素。为了评估临床前期患者中较低BMI水平与肺癌的风险关系，我们基于社区大规模筛查的结果进行了一项病例对照研究。
设计：1993年4月至2003年3月期间，对363例肺癌病例和1089例对照受试者进行了一项病例对照研究，以调查BMI（诊断时以及诊断前1至5年）与肺癌之间的关系。对照受试者从胸部X线摄影和常规实验室检查无异常的大规模筛查受试者中选取。
结果：在男性中，调整年龄和吸烟因素后，观察到BMI与肺癌呈负相关（BMI＜20.8；参照组范围，≥22.9至＜25.0；比值比为1.9；p = 0.0025；95%置信区间为1.3至2.9）。然而，在女性中，未发现BMI与肺癌之间存在关联（BMI＜20.8，p = 0.3868；以及BMI……（此处原文似乎不完整）
Study, objectives: An inverse relationship between body mass index (BMI) and (lie risk of lung cancer, suggesting that leanness is a risk factor for Inn g cancer, has been reported in previous studies. In order to evaluate the risk of lung cancer associated with lower levels of BMI in preclinical patients, we conducted a case-control study based on the results of community mass screening.Design: The relationship between BMI (at the time of diagnosis, and at I to 5 Nears prior to diagnosis) and lung cancer was investigated in a case-control study of :363 lung cancer cases and 1,089 control subjects conducted between April 1993 and March 2003. Control subjects were selected from mass,screening subjects with no abnormalities on chest radiography and routine laboratory tests.Results: In men, an inverse association between BMI and lung cancer was observed after adjustment for age and smoking (BMI < 20.8; range of the referent group, >= 22.9 to < 25.0; odds ratio, 1.9; p = 0.0025; 95% confidence interval, 13 to 2.9). In women, however, no association was found between BMI and lung cancer (BMI < 20.8, p = 0.3868; and BMI