Engineered antifouling microtopographies - correlating wettability with cell attachment
Engineered antifouling microtopographies - correlating wettability with cell attachment
复制标题
DOI：
10.1080/08927010500484854
复制
发表时间：
2006-01-01
期刊：
影响因子：
2.7
通讯作者：
Brennan, AB
中科院分区：
文献类型：
--
作者：
Carman, ML;Estes, TG;Brennan, AB
生物粘附和表面润湿性受微尺度地形的影响。在本研究中，受快速移动的鲨鱼皮肤（Sharklet AF (TM)）启发，在聚二甲基硅氧烷弹性体中复制了工程支柱、山脊和仿生地形。表面上的座滴接触角变化与 Wenzel、Cassie 和 Baxter 的润湿性关系密切相关 (R 2 = 0.89)。两个独立的生物反应，即石莼游动孢子的沉降和猪心血管内皮细胞的排列，与工程通道的宽度（5至20μm之间）成反比。在更精细（约 2 μm）和更复杂的 Sharklet AF (TM) 地形上，游动孢子沉降减少了约 85%。两种细胞类型的反应表明它们的反应受与润湿性相同的基本热力学原理控制。
Bioadhesion and surface wettability are influenced by microscale topography. In the present study, engineered pillars, ridges and biomimetic topography inspired by the skin of fast moving sharks (Sharklet AF (TM)) were replicated in polydimethylsiloxane elastomer. Sessile drop contact angle changes on the surfaces correlated well (R 2 = 0.89) with Wenzel and Cassie and Baxter's relationships for wettability. Two separate biological responses, i.e. settlement of Ulva linza zoospores and alignment of porcine cardiovascular endothelial cells, were inversely proportional to the width (between 5 and 20 mu m) of the engineered channels. Zoospore settlement was reduced by similar to 85% on the finer ( ca 2 mu m) and more complex Sharklet AF (TM) topographies. The response of both cell types suggests their responses are governed by the same underlying thermodynamic principles as wettability.