Prevalence of patent foramen ovale in a large series of patients with migraine with aura, migraine without aura and cluster headache, and relationship with clinical phenotype.
Prevalence of patent foramen ovale in a large series of patients with migraine with aura, migraine without aura and cluster headache, and relationship with clinical phenotype.
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DOI：
10.1007/s10194-005-0223-9
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发表时间：
2005-09-01
期刊：
影响因子：
--
通讯作者：
Padovani, Alessandro
中科院分区：
文献类型：
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作者：
Dalla Volta, Giorgio;Guindani, Massimiliano;Padovani, Alessandro
迄今为止，偏头痛和卵圆孔未闭（PFO）之间的关系已在相对较小的患者系列中观察到。此外，这种关联的确切机制尚不清楚。在本研究中，我们通过对比增强经颅多普勒（TCD）测定了260例先兆偏头痛（MA+）、74例无先兆偏头痛（MA-）和38例丛集性头痛（CH）患者中PFO的患病率。MA+组161例（61.9%）、MA组12例（16.2%）、ch组14例（36.8%）为pfo携带者。这种关联与偏头痛发作的频率和先兆的复杂性无关。最后，在15名在Valsalva演习中至少有一次偏头痛发作史的患者中，只有一名受试者被证明是pfo携带者。我们的研究结果证实了先前观察到的MA+、CH和PFO之间的联系。他们还认为，这种关联与偏头痛的临床表型无关，可能与矛盾栓塞的致病机制无关。
A relationship between migraine and patent foramen ovale (PFO) has been observed in relatively small series of patients so far. Furthermore, the exact mechanism underlying such an association remains unknown. In the present study we determined the prevalence of PFO by contrast-enhanced transcranial Doppler (TCD) in a group of 260 patients with migraine with aura (MA+), 74 patients with migraine without aura (MA-), and 38 patients with cluster headache (CH). One-hundred-sixty-one MA+subjects (61.9%), 12 MA-subjects (16.2%), and 14 CH-subjects (36.8%) were PFO-carriers. The association was independent on the frequency of migraine attacks and complexity of aura. Finally, among the 15 patients who had a history of at least one migraine attack occurring during a Valsalva maneuver only one subject turned out to be PFO-carrier. Our findings confirm previous observations of a link between MA+, CH, and PFO. They also suggest that such an association is independent on migraine clinical phenotype and is probably unrelated to the pathogenic mechanism of paradoxical embolism.