Hippocampal awake replay in fear memory retrieval.
Hippocampal awake replay in fear memory retrieval.
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DOI：
10.1038/nn.4507
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发表时间：
2017-04
影响因子：
25
通讯作者：
Ji D
中科院分区：
文献类型：
--
作者：
Wu CT;Haggerty D;Kemere C;Ji D
海马体位置细胞是情景记忆的关键。这些细胞如何参与记忆提取尚不清楚。在这里，老鼠通过在赛道的震动区接受轻微的脚震获得恐惧记忆后，我们分析了当动物被放回到赛道时的位置细胞，并显示出明显的记忆检索行为：避开震动区。我们发现，尽管动物没有进入休克区，但代表休克区的位置细胞被重新激活了。这种再激活发生在纹波相关的清醒重播位置细胞序列中，这些位置细胞序列编码了从动物当前位置到冲击区的路径，但在单个θ振荡周期内的位置细胞序列中却没有。研究结果揭示了抑制回避行为背后的特定位置细胞模式，为清醒重放参与恐惧记忆提取提供了有力证据。
Hippocampal place cells are key to episodic memories. How these cells participate in memory retrieval remains unclear. Here, after rats acquired a fear memory by receiving mild foot-shocks at a shock zone of a track, we analyzed place cells when the animals were placed back to the track and displayed an apparent memory retrieval behavior: avoidance of the shock zone. We found that place cells representing the shock zone were reactivated, despite the fact that the animals did not enter the shock zone. This reactivation occurred in ripple-associated awake replay of place cell sequences encoding the paths from the animal’s current positions to the shock zone, but not in place cell sequences within individual cycles of theta oscillation. The result reveals a specific place cell pattern underlying the inhibitory avoidance behavior and provides strong evidence for the involvement of awake replay in fear memory retrieval.