BEHAVIORAL AND NEUROCHEMICAL CHANGES ASSOCIATED WITH CHRONIC EXPOSURE TO LOW-LEVEL CONCENTRATION OF PESTICIDE MIXTURES
BEHAVIORAL AND NEUROCHEMICAL CHANGES ASSOCIATED WITH CHRONIC EXPOSURE TO LOW-LEVEL CONCENTRATION OF PESTICIDE MIXTURES
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DOI：
10.1080/15287399009531424
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发表时间：
1990-01-01
期刊：
影响因子：
--
通讯作者：
PORTER, WP
中科院分区：
文献类型：
--
作者：
BOYD, CA;WEILER, MH;PORTER, WP
In order to assess behavioral and neurochemical changes resulting from pesticide exposure, food-restricted male weanling rats were exposed for 90 d to low doses (1 ppb-10,000 ppb range) of individual pesticide (aldicarb, metribuzin, or methomyl) or mixtures of them. During exposure, rats were trained to run a T-maze and tested for spatial discrimination reversal learning. At sacrifice, three brain regions (cortex, hippocampus, and neostriatum) were assayed for the neurotransmitters dopamine, acetylcholine, and serotonin. Animals treated with a mixture of two insecticides and one herbicide were found to have slower speeds in maze-running (motor control) and also had altered levels of choline in their neostriatums. Rats treated with one herbicide compound (metribuzin) took longer to learn on two reversals; this group also had a significantly lower acetylcholine/choline ratio in their hippocampus.
