Familial Hodgkin's disease: A disease of young adulthood?
Familial Hodgkin's disease: A disease of young adulthood?
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DOI：
10.1007/s002770050270
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发表时间：
1997-03-01
影响因子：
3.5
通讯作者：
Boffetta, P
中科院分区：
文献类型：
--
作者：
Ferraris, AM;Racchi, O;Boffetta, P
据估计，家族性霍奇金病（FHD）约占所有霍奇金病（HD）病例的4.5%。共同的环境因素，如EB病毒和其他病毒因子，以及遗传决定因素都被提出来解释HD的家族聚集性。为了比较FHD的特点与那些更常见的散发形式，我们回顾了28篇关于FHD的文章，发表于1972年和1995年之间，并进一步详细分析了18篇论文的数据，共328例患者的报告。FHD人群的男女比例为1.5，与散发性HD的报告相似，但低于一些作者提出的FHD。另一方面，根据诊断时的年龄，散发性和家族性HD之间存在显着差异;也就是说，FHD患者组中仅在15至34岁之间存在一个主要峰值。进一步研究FHD在年轻的成年人可能会提供深入了解疾病的遗传或感染性病因学的假设。
Familial Hodgkin's disease (FHD) is estimated to represent approximately 4.5% of all cases of Hodgkin's disease (HD). Shared environmental factors, such as Epstein-Barr virus and other viral agents, and genetic determinants have all been proposed to explain familial aggregation of HD. In order to compare the characteristic features of FHD with those of the much more common sporadic form, we reviewed 28 articles on FHD, published between 1972 and 1995, and analyzed in further detail data from 18 papers, reporting on a total of 328 patients. The male-to-female ratio of the FHD population examined was 1.5, similar to that reported for sporadic HD, and lower than the one suggested for FHD by some authors. On the other hand, a significant difference was found between sporadic and familial HD according to age at diagnosis; that is, only one major peak between 15 and 34 years was present in the group of patients with FHD. Further investigation of FHD in young adulthood may provide insight into the hypothesis of a genetic or infectious etiology of the disease.