Clinical characteristics of asymptomatic and symptomatic patients with mild COVID-19
Clinical characteristics of asymptomatic and symptomatic patients with mild COVID-19
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DOI：
10.1016/j.cmi.2020.04.040
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发表时间：
2020-07-01
影响因子：
14.2
通讯作者：
Kim, S-H
中科院分区：
文献类型：
--
作者：
Kim, G-u;Kim, M-J;Kim, S-H
目标：详细了解 2019 年冠状病毒病（COVID-19）无症状病例的流行情况和轻度 COVID-19 的临床特征对于有效控制 COVID-19 大流行至关重要。我们确定了 COVID-19 无症状病例的患病率，并描述了轻度 COVID-19 患者的症状特征。方法：研究参与者是从韩国指定用于隔离无中度至重度 COVID-19 症状的患者的社区设施中招募的。通过问卷调查评估入院时无症状患者的患病率以及轻度COVID-19的详细症状。通过实时 RT-PCR 确认了 COVID-19 的诊断。结果：在 213 名 COVID-19 患者中，41 人 (19.2%) 入院前没有症状。在其余轻度 COVID-19 患者中，最常见的症状是咳嗽（40.1%；69/172），其次是嗅觉减退（39.5%；68/172）和咳痰（39.5%；68/172）。在 68 名嗅觉减退患者中，61 人（90%）伴有味觉减退、鼻塞或流鼻涕等伴随症状。仅 20 人（11.6%）出现发烧（37.5℃）。结论：多达五分之一的 COVID-19 患者从接触到入院期间一直没有症状。轻度 COVID-19 患者中出现低烧的情况相当常见，但发烧的情况则不然。应大力实施社交距离，防止无症状或症状轻微、不明显的人传播疾病。 G.-u。 Kim，临床微生物感染 2020；26:948.e1 - 948.e3
Objectives: Detailed knowledge on the prevalence of asymptomatic cases of coronavirus disease 2019 (COVID-19) and the clinical characteristics of mild COVID-19 is essential for effective control of the COVID-19 pandemic. We determined the prevalence of asymptomatic cases of COVID-19 and charac- terized the symptoms of patients with mild COVID-19. Methods: Study participants were recruited from a community facility designated for the isolation of patients without moderate -to -severe symptoms of COVID-19 in South Korea. The prevalence of asymptomatic patients at admission and the detailed symptoms of mild COVID-19 were evaluated through a questionnaire -based survey. Diagnosis of COVID-19 was con firmed by real-time RT-PCR. Results: Of the 213 individuals with COVID-19, 41 (19.2%) were asymptomatic until admission. Among the remaining patients with mild COVID-19, the most common symptom was cough (40.1%; 69/172), followed by hyposmia (39.5%; 68/172) and sputum (39.5%; 68/172). Of the 68 individuals with hyposmia, 61 (90%) had accompanying symptoms such as hypogeusia, nasal congestion or rhinorrhoea. Fever ( 37.5 ? C) was only observed in 20 (11.6%) individuals. Conclusions: As much as one - fifth of individuals with COVID-19 remained asymptomatic from exposure to admission. Hyposmia was quite frequent among individuals with mild COVID-19, but fever was not. Social distancing should be strongly implemented to prevent disease transmission from asymptomatic individuals or those with mild and inconspicuous symptoms. G. -u. Kim, Clin Microbiol Infect 2020;26:948.e1 - 948.e3