Antifouling Indole Alkaloids of a Marine-Derived Fungus Eurotium sp.
Antifouling Indole Alkaloids of a Marine-Derived Fungus Eurotium sp.
复制标题
海洋源性真菌散囊菌的防污吲哚生物碱。
DOI：
10.1007/s10600-018-2301-7
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发表时间：
2018-01-01
影响因子：
0.8
通讯作者：
Wang, Chang-Yun
中科院分区：
文献类型：
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作者：
Chen, Min;Wang, Kai-Ling;Wang, Chang-Yun
海洋污损生物给世界各地的海洋工业和水产养殖设施造成巨大的经济损失。因此，开发高效、环保的防污剂已成为当今的当务之急。海洋微生物已被证明是防污天然化合物的潜在来源[1]。在我们对南海海洋真菌正在进行的研究中，我们分离出了几种具有良好生物活性的新次生代谢物，包括防污活性[2-4]。最近，我们对柳珊瑚衍生的散簇菌进行了化学研究。菌。从真菌培养物中分离出六种吲哚生物碱 (1-6)。其中，化合物4-6具有罕见的螺环-蒽并吡喃-二酮哌嗪部分。化合物 1-3 显示出重要的防污活性。在此，我们报告了这些化合物的分离、结构解析和防污活性。真菌散囊菌属 sp.是从2009年12月采自南海西沙群岛珊瑚礁的新鲜柳珊瑚Subbergorgia suberosa内部分离得到的。该菌株保藏于中华民国青岛市中国海洋大学医学与药学院教育部海洋药物重点实验室，基因库（NCBI）登录号： HM991283。真菌菌株在大米培养基（12 g 天然海盐、100 g 大米、0.6 g 蛋白胨、100 mL H
Marine fouling organisms result in tremendous economic losses to maritime industries and aquaculture facilities around the world. As a result, the development of efficient and environmentally friendly antifouling agents is an urgent task nowadays. Marine microorganisms have been proven to be a potential source of antifouling natural compounds [1]. In our ongoing research on marine fungi from the South China Sea, we have isolated several new secondary metabolites with promising bioactivity, including antifouling activity [2–4]. Recently, we have chemically investigated a gorgonian-derived Eurotium sp. fungus. Six indole alkaloids (1–6) were isolated from the fungal cultures. Among them, compounds 4–6 possess the unusual spiro-anthronopyranoid-diketopiperazine moiety. Compounds 1–3 showed important antifouling activities. Herein we report the isolation, structure elucidation, and antifouling activities of these compounds. The fungus Eurotium sp. was isolated from the inner part of a fresh gorgonian, Subergorgia suberosa, which was collected from the Xisha Islands coral reef in the South China Sea in December 2009. The strain was deposited at the Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Peoplecs Republic of China, with the Genebank (NCBI) accession number, HM991283. The fungal strain was cultivated in a rice medium (12 g of natural seasalt, 100 g of rice, 0.6 g of peptone, 100 mL of H