Age-associated gallstone formation in male and female CCK-1(A) receptor-deficient mice
Age-associated gallstone formation in male and female CCK-1(A) receptor-deficient mice
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DOI：
10.1007/s00535-007-2036-x
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发表时间：
2007-06-01
影响因子：
6.3
通讯作者：
Funakoshi, Akihiro
中科院分区：
文献类型：
--
作者：
Miyasaka, Kyoko;Kanai, Setsuko;Funakoshi, Akihiro
背景。胆囊运动障碍加速胆石症。反过来，胆囊运动障碍可继发于炎症和胆囊平滑肌中过量胆固醇的积累。方法。本研究旨在通过比较胆囊收缩素-1受体基因缺陷[CCK-1R(-/-)]雄性和雌性小鼠，确定胆囊运动障碍对胆结石形成的主要影响程度，以及胆结石形成是否存在性别差异。结果。在6个月大的小鼠中没有观察到污泥或胆结石的形成。12月龄和24月龄时，雌性CCK-IR（-/-）小鼠的污泥和胆结石形成频率略高于雄性，但差异不显著。结论。胆囊运动障碍可能加速污泥和胆结石的形成，但其作用有限。产生胆结石需要12个月的时间，在小鼠达到12个月大后，进一步衰老并没有增加胆结石的频率。性别的影响没有达到显著水平。
Background. Gallbladder dysmotility accelerates cholelithiasis. In turn, gallbladder dysmotility can occur secondary to inflammation and excess cholesterol accumulation in gallbladder smooth muscle. Methods. The present study was designed to determine how much gallbladder dysmotility contributes to gallstone formation as a primary cause and whether a sex difference exists in gallstone formation by comparing cholecystokinin-1 receptor gene-deficient [CCK-1R(-/-)] male and female mice. Results. No sludge or gallstone formation was observed in mice at 6 months of age. The frequency of sludge and gallstone formation in mice at 12 and 24 months of age was slightly higher in female CCK-IR(-/-) mice than in males, but the difference was not significant. Conclusions. Gallbladder dysmotility may have accelerated sludge and gallstone formation, but its contribution was limited. A 12-month period was required to produce gallstones, and after the mice reached 12 months of age, further ageing did not increase the frequency of gallstones. The effect of sex did not reach a significant level.