PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition
PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition
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DOI：
10.1093/bioinformatics/btu310
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发表时间：
2014-09-01
期刊：
影响因子：
5.8
通讯作者：
King, Oliver D.
中科院分区：
文献类型：
--
作者：
Lancaster, Alex K.;Nutter-Upham, Andrew;King, Oliver D.
摘要：朊病毒是一种自我模板的蛋白质聚集体，它稳定地延续了独特的生物状态，是进化和生物医学科学研究人员的浓厚兴趣。人们最了解的朊病毒来自酵母，它们的朊病毒形成结构域具有强烈偏倚的氨基酸组成，最显著的是富含Q或n。PLAAC是一个扫描蛋白质序列的结构域，寻找具有朊病毒样氨基酸组成的网络应用程序。用户可以上传序列文件，或者直接将序列粘贴到文本框中。PLAAC通过几个摘要分数对输入序列进行排名，并允许沿序列的分数可视化。可以下载文本输出文件以进行进一步分析，并以PDF和PNG格式保存可视化文件。
A Summary: Prions are self-templating protein aggregates that stably perpetuate distinct biological states and are of keen interest to researchers in both evolutionary and biomedical science. The best understood prions are from yeast and have a prion-forming domain with strongly biased amino acid composition, most notably enriched for Q or N. PLAAC is a web application that scans protein sequences for domains with prion-like amino acid composition. Users can upload sequence files, or paste sequences directly into a textbox. PLAAC ranks the input sequences by several summary scores and allows scores along sequences to be visualized. Text output files can be downloaded for further analyses, and visualizations saved in PDF and PNG formats.