Constructing multicomponent cooperative functional systems using metal complexes of short flexible peptides
Constructing multicomponent cooperative functional systems using metal complexes of short flexible peptides
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DOI：
10.1039/d1cc03101e
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发表时间：
2021-07-27
影响因子：
4.9
通讯作者：
Miyake, Ryosuke
中科院分区：
文献类型：
--
作者：
Miyake, Ryosuke
构建由多个单元组成的协作系统是人工系统发展与生物系统中发现的复杂功能相当的基本挑战。具有各种官能团的灵活框架可以形成类似于生物系统中观察到的弱分子内/分子间相互作用，对于用于控制协作系统的人工系统具有有前景的设计特征。然而，从精确控制多个单元的协作切换开始，通过控制功能单元的排列，使用这些灵活的单元构建>1 nm的多组件系统是很困难的。一般来说，寡肽虽然具有适合开发协同系统的可设计性和结构特征，但自身很难形成稳定的构象。增加肽中比氢键更强的配位键的数量，由于配位键的多样性和选择性结合亲和力，可用于控制组装的肽结构并稳定其结构。因此，人工短肽的金属配合物在开发多组分协同系统方面具有巨大的潜力。基于这一理念，我们开发了一系列新型柔性肽金属配合物，迄今为止已经实现了协同系统、巨型结构的形成以及对功能单元的精确控制，这是可设计的多功能系统（可被视为人工酶）的重要基础。在这篇专题文章中，我们总结了这些结果并讨论了人工系统的原理/本质设计。
The construction of cooperative systems comprising several units is an essential challenge for artificial systems toward the development of sophisticated functions comparable to those found in biological systems. Flexible frameworks possessing various functional groups that can form weak intra/intermolecular interactions similar to those observed in biological systems have promising design features for artificial systems used to control cooperative systems. However, it is difficult to construct multiple component systems >1 nm using these flexible units by controlling the arrangement of functional units, beginning with the precise control of the cooperative switching of multiple units. In general, it is difficult for oligopeptides to form stable conformations by themselves, although they have designability and structural features suitable for the development of cooperative systems. Increasing the number of coordination bonds in peptides, which are stronger than hydrogen bonds, can be used to control the assembled peptide structures and stabilize their structures owing to the variety of coordination bonds and selective binding affinity. Thus, metal complexes of artificial short peptides have great potential for the development of multicomponent cooperative systems. Based on this concept, we have developed a series of novel metal complexes of flexible peptides and have achieved, to date, cooperative systems, the formation of giant structures, and precise control over the functional units that are the essential bases for designable multifunctional systems that can be regarded as artificial enzymes. In this feature article, we summarize these results and discuss the principal/essential design of artificial systems.