COMPARATIVE EFFECT OF ACTH, CORTISONE AND DCA ON RENAL FUNCTION, ELECTROLYTE EXCRETION AND WATER EXCHANGE IN NORMAL DOGS
COMPARATIVE EFFECT OF ACTH, CORTISONE AND DCA ON RENAL FUNCTION, ELECTROLYTE EXCRETION AND WATER EXCHANGE IN NORMAL DOGS
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DOI：
10.1210/endo-52-3-245
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发表时间：
1953-01-01
期刊：
影响因子：
4.8
通讯作者：
HOWELL, DS
中科院分区：
文献类型：
--
作者：
DAVIS, JO;HOWELL, DS
ACTH、皮质醇和DCA连续给药5~31天，剂量分别为2.1和6.3 mg/kg/d，2.1和4.2 mg/kg/d和1.0 mg/kg/d，2个钠摄入量水平(0.5和3.3 meq./kg/d)。肾小球滤过率(GFR)和肾血浆流量均随3种激素的增加而增加(除1只狗的ACTH和另1只狗的DCA外)，其中以可的松作用最明显，DCA作用最小。水分交换均有不同程度的增加。DCA引起的尿崩症状态依赖于高钠摄入量，而在低钠饮食和高钠饮食中，ACTH和可的松都会导致较小幅度的水周转增加。ACTH、可的松和DCA均为负K平衡，但DCA和高盐摄入量存在明显的K耗竭和碱中毒。DCA能显著增加粪钾排泄量，ACTH能轻微增加粪钾排泄量(3/4只犬)，但对可的松无明显影响。ACTH和可的松用药前1~2天。在4只狗中有3只伴有盐分丢失；由于这3只狗最初GFR增加，而第4只动物没有，提示GFR升高与负平衡之间存在因果关系。盐分滞留发生在DCA的同一时期。此后，在管理期间保持了平衡。在所有三种激素中，尽管GFR很高。虽然尚不确定ACTH是否刺激激素的分泌，促进肾小管对钠和氯的重吸收，但ACTH和可的松对狗排盐的影响与已报道的人类不同。
ACTH cortisone, and DCA were administered successively for periods of 5-31 days to 4 dogs, at dosage levels (in mg./kg./ day) of 2.1 and 6.3 of ACTH, 2.1 and 4.2 of cortisone and 1.0 of DCA, and at 2 levels of Na intake (0.5 and 3.3 meq./kg./day). Glomerular filtration rate (GFR) and renal plasma flow increased with all 3 hormones (except with ACTH in 1 dog and DCA in another), most markedly with cortisone, least with DCA. Water exchange was increased by all 3 prepns. The diabetes insipidus-like state produced by DCA was dependent upon a high Na intake, whereas increased water turnover of lesser magnitude occurred with ACTH and cortisone on both low and high Na diets. A negative K balance resulted with ACTH, cortisone, and DCA but marked K depletion and alkalosis accompanied DCA and a high salt intake only. Fecal K excretion was increased greatly by DCA and slightly by ACTH (3 of 4 dogs) but cortisone was without effect. The first 1 or 2 days of ACTH and cortisone admn. were accompanied by salt loss in 3 of the 4 dogs; since GFR was initially increased in these 3 but not in the 4th animal, a causal relationship between elevated GFR and the negative balance is suggested. Salt retention resulted during the corresponding period on DCA. Thereafter, balance was maintained during admn. of all 3 hormones in spite of a high GFR. Although it is uncertain whether ACTH stimulated secretion of hormones promoting Na and Cl reabsorption by the renal tubules, the effect of ACTH and cortisone on salt excretion in the dog differs from that reported for man.