Long-Term Survivors of Pancreatic Cancer: A California Population-Based Study.
Long-Term Survivors of Pancreatic Cancer: A California Population-Based Study.
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DOI：
10.1097/mpa.0000000000001133
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发表时间：
2018-09
期刊：
影响因子：
2.9
通讯作者：
Clarke CA
中科院分区：
文献类型：
--
作者：
Kardosh A;Lichtensztajn DY;Gubens MA;Kunz PL;Fisher GA;Clarke CA
补充的数字内容可在文本中找到。胰腺癌的预后仍然很差，生存率在过去40年里几乎没有改善。我们报告了一项基于人群的综合分析，分析了加州不同人群中诊断出的胰腺腺癌长期幸存者。来自加州癌症登记处的数据被用来评估长期生存率。在1988年至2009年间，共有70,442名被诊断为胰腺腺癌的患者被确定。使用逻辑回归来确定与实现5年生存相关的因素。总的5年生存率为2.5%，在30年的时间里只有很小的改善。年龄、分期、分化程度和手术切除与5年生存率相关。此外，年龄较小和在国家癌症研究所指定的癌症中心接受治疗与5年生存率相似，无论手术干预如何。此外，我们确定了分期、分化和辅助化疗是手术切除患者长期生存的重要因素。在不能切除的患者中，亚洲/太平洋岛民和西班牙裔明显比非西班牙裔白人更有可能达到5年的里程碑。尽管胰腺癌死亡率仍然很高，但我们的研究强调了与长期生存相关的基线特征、治疗、生物学因素和种族。这些发现可以作为进一步研究的跳板。
Supplemental digital content is available in the text. Pancreatic cancer continues to carry a poor prognosis with survival rates that have had minimal improvement over the past 4 decades. We report a population-based, comprehensive analysis of long-term survivors of pancreatic adenocarcinoma diagnosed in the diverse population of California. Data from the California Cancer Registry were used to evaluate long-term survival. A total of 70,442 patients diagnosed with pancreatic adenocarcinoma between 1988 and 2009 were identified. Logistic regression was used to identify factors associated with achieving 5-year survival. The overall 5-year survival was 2.5%, with minimal incremental improvements throughout the 3 decades. Age, stage, degree of differentiation, and surgical resection were associated with 5-year survival. Furthermore, younger age and receiving care at a National Cancer Institute–designated cancer center were similarly correlated with 5-year survival regardless of surgical intervention. In addition, we identified stage, differentiation, and adjuvant chemotherapy as significant factors for long-term survival in surgically resected patients. In the unresectable patients, Asian/Pacific islanders and Hispanics were significantly more likely to reach the 5-year milestone than non-Hispanic whites. Although pancreatic cancer mortality remains high, our study highlights baseline characteristics, treatment, biological factors, and ethnicity that are associated with long-term survival. These findings may serve as a springboard for further investigation.