LUNG-CANCER IN RELATION TO ENVIRONMENTAL-POLLUTANTS EMITTED FROM INDUSTRIAL SOURCES
LUNG-CANCER IN RELATION TO ENVIRONMENTAL-POLLUTANTS EMITTED FROM INDUSTRIAL SOURCES
复制标题
DOI：
10.1016/0013-9351(84)90093-8
复制
发表时间：
1984-01-01
影响因子：
8.3
通讯作者：
BLOT, WJ
中科院分区：
文献类型：
--
作者：
BROWN, LM;POTTERN, LM;BLOT, WJ
对居住在宾夕法尼亚州东部一家原锌冶炼厂和一家大型钢铁制造厂附近的居民进行了一项病例对照研究，以调查环境污染物在肺癌病因学中的作用。从335例白色男性肺癌病例和332例白色男性对照的近亲中获得了终生居住、职业和吸烟史。采集土壤样品，分析As、Cu、Pb、Mn、Zn和Cd的含量（ppm）。根据居住地与锌冶炼厂和钢铁厂的距离，以及居住地与各种污染物的轻重程度，确定了相对风险。肺癌的双重风险与居住在锌冶炼厂附近和居住在砷和镉含量高的地区有关，尽管居住在这些高风险地区的人数很少。这些增长不能用吸烟的影响或锌或钢铁行业的就业来解释。住在钢铁厂附近没有额外的风险。研究规模有限，无法解释因果关系，但研究结果表明，需要进一步调查金属空气污染和肺癌。
A case-control study of residents who lived in the vicinity of a primary Zn smelter and a large steel manufacturing plant in eastern Pennsylvania [USA] was undertaken to investigate the role of environmental pollutants in the etiology of lung cancer. Lifetime residential, occupational and smoking histories were obtained from the next of kin of 335 white male lung cancer cases and 332 white male controls. Soil samples were collected and analyzed for content (parts/million) of As, Cu, Pb, Mn, Zn and Cd. Relative risks were determined according to distance of residence from the Zn smelter and the steel plant, and according to residence in areas with heavy and light levels of various pollutants. Two-fold risks for lung cancer were associated with residence near the Zn smelter and with residence in areas with heavy levels of As and Cd, although the number of individuals living in these higher risk areas was small. These increases were not explained by the effects of cigarette smoking or by employment in the Zn or steel industry. No excess risk was associated with living near the steel plant. The limited size of the study precluded causal interpretation, but the findings suggested the need for further investigation of metallic air pollution and lung cancer.