Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers.
Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers.
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DOI：
10.1016/j.ccell.2015.09.006
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发表时间：
2015-10-12
期刊：
影响因子：
50.3
通讯作者：
Zhang L
中科院分区：
文献类型：
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作者：
Yan X;Hu Z;Feng Y;Hu X;Yuan J;Zhao SD;Zhang Y;Yang L;Shan W;He Q;Fan L;Kandalaft LE;Tanyi JL;Li C;Yuan CX;Zhang D;Yuan H;Hua K;Lu Y;Katsaros D;Huang Q;Montone K;Fan Y;Coukos G;Boyd J;Sood AK;Rebbeck T;Mills GB;Dang CV;Zhang L
长非编码RNA(LncRNA)的发现极大地改变了我们对癌症的理解。在这里，我们描述了来自癌症基因组图谱(TCGA)的来自13种癌症类型的5,037例人类肿瘤标本在转录、基因组和表观遗传水平上的lncRNA变化的综合分析。我们的结果表明，与编码蛋白质的基因相比，lncRNAs的表达和失调具有高度的癌症类型特异性。利用这一分析产生的综合数据，我们提出了临床指导的小干扰RNA筛选策略和共表达分析方法，以识别癌症驱动因素lncRNA并预测其功能。这为研究癌症中的lncRNAs提供了资源，并为开发新的诊断和治疗方法奠定了基础。
The discovery of long non-coding RNA (lncRNA) has dramatically altered our understanding of cancer. Here, we describe a comprehensive analysis of lncRNA alterations at transcriptional, genomic, and epigenetic levels in 5,037 human tumor specimens across 13 cancer types from the Cancer Genome Atlas (TCGA). Our results suggest that the expression and dysregulation of lncRNAs are highly cancer-type specific compared to protein-coding genes. Using the integrative data generated by this analysis, we present a clinically guided small interfering RNA screening strategy and a co-expression analysis approach to identify cancer driver lncRNAs and predict their functions. This provides a resource for investigating lncRNAs in cancer and lays the groundwork for the development of new diagnostics and treatments.