AN INTERNAL RADIATION DOSIMETRY COMPUTER PROGRAM, IDAC 2.0, FOR ESTIMATION OF PATIENT DOSES FROM RADIOPHARMACEUTICALS
AN INTERNAL RADIATION DOSIMETRY COMPUTER PROGRAM, IDAC 2.0, FOR ESTIMATION OF PATIENT DOSES FROM RADIOPHARMACEUTICALS
复制标题
DOI：
10.1093/rpd/nct337
复制
发表时间：
2014-12-01
影响因子：
1
通讯作者：
Leide-Svegborn, S.
中科院分区：
文献类型：
--
作者：
Andersson, M.;Johansson, L.;Leide-Svegborn, S.
本文介绍了用于计算放射性药物检查中器官和组织的吸收剂量以及病人的有效剂量的计算机内剂量评估程序IDAC。新版本IDAC2.0结合了国际辐射防护委员会（ICRP）/ICRU计算成年男性和女性体素幻影和衰变数据，来自ICRP出版物107。代替仅25个源区域和目标区域，现在可以用63个源区域到73个目标区域进行计算。使用新体模的主要优点是可以使用ICRP出版物103的最新组织加权因子计算有效剂量。IDAC 2.0使用ICRP人体消化道（HAT）模型进行口服给药活性和胃肠道排泄，并重新计算了口服放射性药物的有效剂量。该程序的结果与使用相同比吸收分数的已发表数据一致，并且还与来自相同计算模型的已发表数据进行了比较，但器官分割导致另一组比吸收分数。对所有34种口服给药的放射性药物重新计算有效剂量，并由ICRP公布。使用新的HAT模型，新的组织加权因子和新的成人计算体素幻影导致其早期估计值的一半的平均有效剂量。减少主要取决于电子输运模拟壁器官和过渡的风格化的幻影与不切实际的器官间的距离，以更现实的体素幻影。
The internal dosimetry computer program internal dose assessment by computer (IDAC) for calculations of absorbed doses to organs and tissues as well as effective doses to patients from examinations with radiopharmaceuticals has been developed. The new version, IDAC2.0, incorporates the International Commission on Radiation Protection (ICRP)/ICRU computational adult male and female voxel phantoms and decay data from the ICRP publication 107. Instead of only 25 source and target regions, calculation can now be made with 63 source regions to 73 target regions. The major advantage of having the new phantom is that the calculations of the effective doses can be made with the latest tissue weighting factors of ICRP publication 103. IDAC2.0 uses the ICRP human alimentary tract (HAT) model for orally administrated activity and for excretion through the gastrointestinal tract and effective doses have been recalculated for radiopharmaceuticals that are orally administered. The results of the program are consistent with published data using the same specific absorption fractions and also compared with published data from the same computational phantoms but with segmentation of organs leading to another set of specific absorption fractions. The effective dose is recalculated for all the 34 radiopharmaceuticals that are administered orally and has been published by the ICRP. Using the new HAT model, new tissue weighting factors and the new adult computational voxel phantoms lead to an average effective dose of half of its earlier estimated value. The reduction mainly depends on electron transport simulations to walled organs and the transition from the stylised phantom with unrealistic interorgan distances to more realistic voxel phantoms.