ROLE OF SURFACE-ACTIVE PHOSPHOLIPIDS IN GASTRIC CYTOPROTECTION
ROLE OF SURFACE-ACTIVE PHOSPHOLIPIDS IN GASTRIC CYTOPROTECTION
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DOI：
10.1126/science.6828859
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发表时间：
1983-01-01
期刊：
影响因子：
56.9
通讯作者：
HILLS, BA
中科院分区：
文献类型：
--
作者：
LICHTENBERGER, LM;GRAZIANI, LA;HILLS, BA
胃内给予脂质体表面活性剂悬浮液可显着减少大鼠中酸诱导的胃溃疡发生和出血。通过给予16,16-二甲基前列腺素E2，胃粘膜中固有的表面活性分子的浓度增加了2-6倍。因此，表面活性磷脂的局部积累可能是前列腺素治疗激活的细胞保护机制的一个组成部分。
Intragastric administration of a liposomal surfactant suspension markedly reduced acid-induced gastric ulcerogenesis and bleeding in rats. The concentration of surface-active molecules intrinsically present in the gastric mucosa was increased 2-6 times by administration of 16,16-dimethyl prostaglandin E2. Thus, local accumulation of surface-active phospholipids may be an integral component of the cytoprotective mechanism activated by prostaglandin treatment.