The importance of selenium and the effects of its deficiency in animal health
The importance of selenium and the effects of its deficiency in animal health
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DOI：
10.1016/j.smallrumres.2009.12.042
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发表时间：
2010-04-01
影响因子：
1.8
通讯作者：
Tortora-Perez, J. L.
中科院分区：
文献类型：
--
作者：
El Ghany Hefnawy, Abd;Tortora-Perez, J. L.
硒是动物营养中必需的微量元素，具有与动物生产、繁殖和疾病预防有关的多种作用。谷胱甘肽过氧化物酶（GSH-PX）是第一个被证实能防止细胞膜氧化损伤的硒酶。实际上，已经描述了30多种硒酶，并且已经建立了在动物中表达的分级过程。白色肌肉病（WMD）是第一个被确认的与硒缺乏相关的疾病。大规模毁灭性武器造成新生儿死亡，特别是反刍动物死亡，并损害生长期和成年动物的生产条件。硒对甲状腺激素的合成至关重要，它对将T4（甲状腺素非活性形式）转化为T3（活性形式）也非常重要。良好的免疫反应也需要硒。土壤、动植物血液和组织中的硒含量可作为诊断缺硒的指标。补硒剂的形式多种多样，但影响补硒效果的因素很多，如补硒剂的化学形式、动物的健康状况和生产条件等。胎儿硒代谢与孕母硒营养状况的关系对生产力至关重要，需要进一步研究。(C)2010 Elsevier B. V.保留所有权利。
Selenium (Se) is an essential trace element in animal nutrition, and exerts multiple actions related to animal production, fertility and disease prevention. Glutathione peroxidase (GSH-PX) enzyme was the first proven selenoenzyme that can prevent oxidative damage of the cellular membrane. Actually more than 30 selenoenzymes have been described and a hierarchy process for expression in the animal has been established. White muscle disease (WMD) was the first recognized condition associated with Se deficiency. WMD causes new born mortality, especially in ruminants, and impaired production condition in growing and adult animals. Selenium is critical to thyroid hormone synthesis and it is also very important for converting T4 (thyroxin inactive form) to T3 (active form). A good immune response requires Se too. Selenium status in soil, plants and animal blood and tissue can be used in the diagnosis of Se deficiency. Diverse forms of Se supplements are available, but many factors affect their activity and efficacy, such as its chemical form and animal's health and production condition. The relationships between foetus Se metabolism and pregnant dam Se status are critical for productivity and need further research. (C) 2010 Elsevier B.V. All rights reserved.