ABSENCE OF CORRELATION BETWEEN CORONARY ARTERIAL ATHEROSCLEROSIS AND SEVERITY OR DURATION OF DIABETES-MELLITUS OF ADULT ONSET
ABSENCE OF CORRELATION BETWEEN CORONARY ARTERIAL ATHEROSCLEROSIS AND SEVERITY OR DURATION OF DIABETES-MELLITUS OF ADULT ONSET
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DOI：
10.1016/0002-9149(80)90500-7
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发表时间：
1980-01-01
影响因子：
2.8
通讯作者：
HUTCHINS, GM
中科院分区：
文献类型：
--
作者：
VIGORITA, VJ;MOORE, GW;HUTCHINS, GM
糖尿病的严重程度和持续时间与缺血性心脏病的严重程度之间的关系尚不确定。研究了185例成人发病糖尿病患者的临床表现和尸检结果，这些患者年龄从37岁到91岁不等，在死亡前几天到50年内被诊断为糖尿病。临床诊断的糖尿病严重程度或持续时间与总体冠状动脉疾病、病变血管数量或心肌梗死数量之间的简单相关性或多变量回归分析均未显示出统计学显著相关性。多变量分析中存在其他预期相关性，表明本研究的结果并非虚假。然而，与185名年龄和性别匹配的对照组患者相比，平均而言，糖尿病患者有更多的总体冠心病冠脉病变的弥漫性（P <0.005）、冠状动脉侧支病变（P <0.001）、动脉粥样硬化累及血管（P <0.001）、心肌梗死（P < 0.001）。结果表明，虽然成人发病的糖尿病是一种条件，其中较大的冠状动脉比那些在非糖尿病受试者受到更多的动脉粥样硬化，动脉粥样硬化疾病的进展是无关的糖尿病的持续时间或严重程度。
The relation between the severity and duration of diabetes mellitus and the severity of ischemic heart disease is uncertain. The clinical findings and the findings at autopsy were studied in 185 patients with diabetes mellitus of adult onset who ranged in age from 37 to 91 years and had a clinical diagnosis of diabetes established for a few days to 50 years before death. No statistically significant association was demonstrated either by simple correlation or by multivariate regression analysis between the clinically diagnosed severity or duration of diabetes and either the overall coronary disease, the number of diseased vessels or the number of myocardial infarctions. The presence of other expected correlations in the multivariate analysis suggested that the results of this study were not spurious. However, comparison with 185 age- and sex-matched control patients revealed thaton the average, diabetic patients have more overall coronary disease (p < 0.002), more diffuseness of coronary disease (p < 0.005), more coronary collateralizatlon (p < 0.001), more vessels involved by atherosclerosis (p < 0.001) and more myocardial infarcts (p < 0.001). The results suggest that although diabetes mellitus of adult onset is a condition in which the larger coronary arteries are subject to more atherosclerosis than are those in nondiabetic subjects, the progression of the atherosclerotic disease is unrelated to the duration or severity of the diabetes mellitus.