Theophylline pharmacokinetics after intravenous infusion with ethylenediamine or sodium glycinate.
Theophylline pharmacokinetics after intravenous infusion with ethylenediamine or sodium glycinate.
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静脉输注乙二胺或甘氨酸钠后茶碱的药代动力学。
DOI：
10.1111/j.1365-2125.1986.tb02899.x
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发表时间：
1986
影响因子：
3.4
通讯作者：
M. Siebert
中科院分区：
文献类型：
--
作者：
J. Caldwell;A. Staib;I. Cotgreave;M. Siebert
在随机交叉设计中，6名健康志愿者通过短时间静脉输注两种茶碱制剂，每隔一周进行一次。增溶剂为乙二胺或甘氨酸钠。在给药后24小时内，用高效液相色谱法测定血浆中茶碱和乙二胺的浓度。茶碱的药代动力学没有显示出与所用增溶剂相关的任何显着的受试者内部变化。
Six healthy volunteers received two theophylline preparations by short intravenous infusion, at weekly intervals in a randomized cross-over design. The solubilizer was ethylenediamine or sodium glycinate. Plasma concentrations of theophylline and ethylenediamine were measured by h.p.l.c. for up to 24 h after dosing. The pharmacokinetics of theophylline did not show any significant intra-subject variation associated with the solubilizing agent used.