General Last-Step Labeling of Biomolecule-Based Substrates by [12C], [13C], and [11C] Carbon Monoxide
General Last-Step Labeling of Biomolecule-Based Substrates by [12C], [13C], and [11C] Carbon Monoxide
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DOI：
10.1021/ol503471e
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发表时间：
2015-01-16
期刊：
影响因子：
5.2
通讯作者：
Fouquet, Eric
中科院分区：
文献类型：
--
作者：
Cornilleau, Thomas;Audrain, Helene;Fouquet, Eric
基于生物碱、类固醇、生物素、碳水化合物、核苷和肽的生物结合物很容易通过最后一步钯催化的羰基化用 CO 标记。 [C-12]、[C-13] 或 [C-11] 同位素的选择为一类新的潜在示踪剂或配体开辟了道路，可轻松用于各种应用。
Alkaloid-, steroid-, biotin-, carbohydrate-, nucleoside-, and peptide-based bioconjugates are easily labeled with CO by a last-step palladium-catalyzed carbonylation. The choice of the [C-12], [C-13], or [C-11] isotope opens the way to a new class of potential tracers or ligands easily available for various applications.