Outstanding Scientific Achievement Award Lecture 2010: deconstructing leptin: from signals to circuits.
Outstanding Scientific Achievement Award Lecture 2010: deconstructing leptin: from signals to circuits.
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DOI：
10.2337/db10-1118
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发表时间：
2010-11
期刊：
影响因子：
7.7
通讯作者：
Myers MG Jr
中科院分区：
文献类型：
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作者：
Myers MG Jr
马丁·G小迈尔斯，2010年6月28日，在佛罗里达奥兰多举行的美国糖尿病协会第70届科学会议上，医学博士和博士获得了该协会享有盛誉的2010年杰出科学成就奖。杰出科学成就奖旨在表彰糖尿病领域的杰出科学成就，同时考虑到思想的独立性和原创性。目前，Marilyn H.作为密歇根大学安阿伯分校糖尿病研究的Vincent教授和密歇根大学医学院内科学和分子与综合生理学副教授，Myers博士在Joslin糖尿病中心/哈佛医学院Morris白色博士的实验室当研究生时开始了他令人印象深刻的糖尿病研究记录。在那里，迈尔斯博士破译了许多胰岛素受体底物蛋白参与的胰岛素信号通路。1997年从哈佛MD-PhD项目毕业后，迈尔斯博士被晋升为乔斯林糖尿病中心/哈佛医学院的医学讲师。他通过建立一个分子框架来理解瘦素信号传导的机制，包括瘦素受体上的单个磷酸化位点如何招募不同的信号分子，开始了他的独立工作。1999年他被提升为哈佛大学的助理教授。2004年，迈尔斯博士搬到密歇根大学，在那里他建立了瘦素信号传导的分子框架，以探索个体瘦素信号对代谢的调节。Myers博士的实验室揭示了瘦素信号在代谢控制中的特异性，包括瘦素-STAT 3信号在能量平衡和葡萄糖稳态调节中的作用。他的研究小组还确定了瘦素受体反馈抑制和下丘脑mTor信号在代谢中的作用。迈尔斯博士的实验室最近开发了新的分子方法来阐明瘦素调节的大脑回路，这些回路有助于代谢控制，从而能够发现新的大脑系统及其功能。1998年，迈尔斯博士因其科学能力获得了美国糖尿病协会的职业发展奖。迈尔斯博士目前的支持包括国家糖尿病、消化和肾脏疾病研究所的MERIT奖。
Martin G. Myers Jr., MD, PhD, received the American Diabetes Association's prestigious 2010 Outstanding Scientific Achievement Award at the Association's 70th Scientific Sessions in Orlando, Florida, on 28 June 2010. The Outstanding Scientific Achievement Award recognizes outstanding scientific achievement in the field of diabetes, taking into consideration independence of thought and originality. Currently the Marilyn H. Vincent Professor of Diabetes Research at the University of Michigan, Ann Arbor, and Associate Professor in internal medicine and in molecular and integrative physiology at the University of Michigan Medical School, Dr. Myers began his impressive track record in diabetes research as a graduate student in the laboratory of Dr. Morris White at the Joslin Diabetes Center/Harvard Medical School. There, Dr. Myers deciphered many of the insulin signaling pathways engaged by insulin receptor substrate proteins. Following his graduation from the Harvard MD-PhD Program in 1997, Dr. Myers was promoted to instructor in medicine at the Joslin Diabetes Center/Harvard Medical School. He began his independent work by building a molecular framework for understanding the mechanisms of leptin signaling, including how individual phosphorylation sites on the leptin receptor recruit distinct signaling molecules. He was promoted to assistant professor at Harvard in 1999. In 2004, Dr. Myers moved to the University of Michigan, where he built upon the molecular framework of leptin signaling to probe the regulation of metabolism by individual leptin signals. Dr. Myers' laboratory revealed the specificity of leptin signals in metabolic control, including the role for leptin-STAT3 signaling in the regulation of energy balance and glucose homeostasis. His group also defined roles for leptin receptor feedback inhibition and hypothalamic mTor signaling in metabolism. Dr. Myers' laboratory has recently developed novel molecular approaches to elucidate the leptin-regulated brain circuits that contribute to metabolic control, enabling the discovery of novel brain systems and their functions. In 1998, Dr. Myers received the American Diabetes Association's Career Development Award for his scientific abilities. Dr. Myers' current support includes the National Institute of Diabetes and Digestive and Kidney Diseases MERIT Award.