CHARACTERIZATION OF THE HUMAN FACTOR-VIII GENE
CHARACTERIZATION OF THE HUMAN FACTOR-VIII GENE
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DOI：
10.1038/312326a0
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发表时间：
1984-01-01
期刊：
影响因子：
64.8
通讯作者：
LAWN, RM
中科院分区：
文献类型：
--
作者：
GITSCHIER, J;WOOD, WI;LAWN, RM
完整的186，000个碱基对（bp）的人因子VIII基因已被分离出来，由26个外显子和内含子组成，外显子大小从69到3，106 bp不等，内含子大小为32.4 kb。9 kb的mRNA和蛋白质编码DNA已被测序，mRNA末端已被映射。因子VIII的内部重复和基因进化之间的关系进行了讨论。
The complete 186,000 base-pair (bp) human factor VIII gene has been isolated and consists of 26 exons ranging in size from 69 to 3,106 bp and introns as large as 32.4 kilobases (kb). Nine kb of mRNA and protein-coding DNA has been sequenced and the mRNA termini have been mapped. The relationship between internal duplications in factor VIII and evolution of the gene is discussed.