Race- and Sex-Related Differences in Retinal Thickness and Foveal Pit Morphology
Race- and Sex-Related Differences in Retinal Thickness and Foveal Pit Morphology
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DOI：
10.1167/iovs.10-5886
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发表时间：
2011-01-01
影响因子：
4.4
通讯作者：
Carroll, Joseph
中科院分区：
文献类型：
--
作者：
Wagner-Schuman, Melissa;Dubis, Adam M.;Carroll, Joseph
目的。方法：应用光谱域光学相干断层扫描(SD-OCT)检查黄斑厚度和黄斑中心凹形态的性别和种族差异。方法：90例(女性43例，男性47例)180只眼接受了光谱域OCT视网膜成像。每一次黄斑体积扫描的侧向标尺通过眼部生物测量法校正眼轴长度的个体差异。根据这些校正后的体积，生成早期治疗糖尿病视网膜病变研究(ETDRS)视网膜厚度的网格，并在两组之间进行比较。结果：与高加索人相比，非洲人和非裔美国人的中央亚野厚度减小。与男性相比，女性的中央亚野厚度也减少了，尽管女性在黄斑旁区域也显示出明显的变薄。黄斑中心凹形态上没有性别差异；然而，非洲人/非裔美国人的黄斑中心凹明显比高加索人深和宽。结论：先前的研究报告了黄斑厚度的种族和性别差异，推断这些差异代表了相似的解剖特征。然而，在本研究中收集的关于凹坑形态的数据揭示了一个重要而显著的变化。性别之间的差异是由于视网膜厚度的全球差异，而种族之间观察到的厚度差异似乎是由中心凹形态的差异驱动的。这些差异对SD-OCT在检测和诊断视网膜疾病中的应用具有重要意义。(投资眼科VS科学。2011年；52：625-634)doi：10.1167/iovs.10-5886
PURPOSE. To examine sex-and race-associated differences in macular thickness and foveal pit morphology by using spectral-domain optical coherence tomography (SD-OCT).METHODS. One hundred eighty eyes of 90 healthy patients (43 women, 47 men) underwent retinal imaging with spectral-domain OCT. The lateral scale of each macular volume scan was corrected for individual differences in axial length by ocular biometry. From these corrected volumes, Early Treatment Diabetic Retinopathy Study (ETDRS) grids of retinal thickness were generated and compared between the groups. Foveal morphology was measured with previously described algorithms.RESULTS. Compared with the Caucasians, the Africans and African Americans had reduced central subfield thickness. Central subfield thickness was also reduced in the women compared with the men, although the women also showed significant thinning in parafoveal regions. There was no difference between the sexes in foveal pit morphology; however, the Africans/African Americans had significantly deeper and broader foveal pits than the Caucasians.CONCLUSIONS. Previous studies have reported race-and sex-associated differences in macular thickness, and the inference has been that these differences represent similar anatomic features. However, the data on pit morphology collected in the present study reveal an important and significant variation. Between the sexes, the differences are due to global variability in retinal thickness, whereas the variation in thickness observed between the races appears to be driven by differences in foveal pit morphology. These differences have important implications for the use of SD-OCT in detecting and diagnosing retinal disease. (Invest Ophthalmol Vis Sci. 2011;52:625-634) DOI:10.1167/iovs.10-5886