Age- and gender-specific prevalence of carotid atherosclerosis and its association with metabolic syndrome in Hangzhou, China
Age- and gender-specific prevalence of carotid atherosclerosis and its association with metabolic syndrome in Hangzhou, China
复制标题
中国杭州市不同年龄和性别的颈动脉粥样硬化患病率及其与代谢综合征的关系
DOI：
10.1111/j.1365-2265.2011.04198.x
复制
发表时间：
2012-06-01
影响因子：
3.2
通讯作者：
Yu, Yi-Ping
中科院分区：
文献类型：
--
作者：
Yin, Jun-Hua;Song, Zhen-Ya;Yu, Yi-Ping
目的由于生活方式的快速改变和代谢综合征(METS)的发生，中国颈动脉粥样硬化(CA)和颈动脉斑块(CP)的患病率可能会增加。我们的目的是评估CA和CP在华东地区人群中的患病率及其与蛋氨酸代谢综合征的关系。方法研究对象为2009年接受颈动脉超声检查的6142名健康体检者。METS的诊断是根据修订的成人治疗小组III标准进行的。结果CA和CP的患病率随着年龄的增长而逐渐升高。这些疾病在男性中比在女性中更常见(CA：22.1%比12.0%，P<；0.001；CP：12.6%比7.2%，P<；0.001)。多因素Logistic回归分析显示，男性性别、年龄、血压、空腹血糖和低密度脂蛋白胆固醇是CA和CP的危险因素，而高密度脂蛋白胆固醇对CA有保护作用。年龄=50岁对CA和CP的影响最大，其次是血压升高和血糖升高。患有甲状旁腺素患者的CA(男性27.7%vs20.0%，女性24.0%vs10.3%；P<；0.001)和CP(男性16.6%vs11.2%，P<；0.001；女性11.8%vs6.5%，P<；0.005)均高于未患METS者。CA和CP的患病率和优势比随着蛋氨酸成分的增加而聚集，即使在只表现出一种成分的个体中也是如此。结论CA和CP已成为中国地区的主要公共卫生问题。蛋氨酸及其成分与CA和CP的患病率增加相关。
Objective Because of rapid alterations in lifestyle and the incidence of metabolic syndrome (MetS), the prevalence of carotid atherosclerosis (CA) and carotid plaque (CP) may increase in China. We aimed to evaluate the prevalence of CA and CP as well as its relation to MetS in an East Chinese population. Methods The study included 6142 subjects who underwent general health screening including carotid ultrasonography in 2009. Diagnoses of MetS were made according to the revised Adult Treatment Panel III criteria. Results The prevalence of CA and CP increased gradually with age. These conditions were more prevalent in men than in women (CA: 22.1%vs 12.0%, P < 0.001; CP: 12.6%vs 7.2%, P < 0.001). Multivariate logistic regression analysis showed that male gender, age, blood pressure, fasting blood glucose (FBG) and low-density lipoprotein cholesterol were risk factors for CA and CP, while high-density lipoprotein cholesterol was protective for CA. Age =50 years has the largest impact on CA and CP, followed by elevated blood pressure and elevated blood glucose. Individuals with MetS had a higher prevalence of CA (27.7%vs 20.0% in men, 24.0%vs 10.3% in women; P < 0.001 in both) and CP (16.6%vs 11.2% in men, P < 0.001; 11.8%vs 6.5% in women, P < 0.005) than those without MetS. The prevalence and odds ratios of CA and CP aggregated with an increasing number of MetS components, even in individuals exhibiting only one component. Conclusions These results indicate that CA and CP have become a major public health problem in China. MetS and its components were associated with an increased prevalence of CA and CP.