Multi-phenotypic Role of Serum Response Factor in the Gastrointestinal System.
Multi-phenotypic Role of Serum Response Factor in the Gastrointestinal System.
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DOI：
10.5056/jnm15183
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发表时间：
2016-04-30
影响因子：
3.4
通讯作者：
Ro S
中科院分区：
文献类型：
--
作者：
Ro S
血清反应因子（SRF）是肌动蛋白细胞骨架的主要转录因子，其结合位于大多数平滑肌细胞（SMC）限制性启动子/增强子内的高度保守的CArG盒。虽然大多数SRF的研究集中在骨骼肌，心肌和血管平滑肌细胞，SRF的研究最近扩展到胃肠道（GI）系统。GI SMC转录组和CArG盒（CArGome）的基因组规模分析已确定了新的SRF靶基因。除了环形和纵向平滑肌层之外，SRF还在GI粘膜和癌症中表达。在胃肠道中，SRF是参与细胞凋亡、去分化、增殖和迁移的基因的中心调节因子。由于SRF是细胞表型调节剂，它可能在胃肠道内肌病、肥大、溃疡、胃癌和结肠癌的发展中起重要作用。鉴于SRF在消化系统中所显示的多功能作用，SRF作为潜在的治疗靶点受到了更多的关注。这篇综述总结了SRF研究中有关胃肠道的发现，并对未来的发展方向提供了有价值的见解。
Serum response factor (SRF) is a master transcription factor of the actin cytoskeleton that binds to highly conserved CArG boxes located within the majority of smooth muscle cell (SMC)-restricted promoters/enhancers. Although most studies of SRF focus on skeletal muscle, cardiac muscle, and vascular SMCs, SRF research has recently expanded into the gastrointestinal (GI) system. Genome scale analyses of GI SMC transcriptome and CArG boxes (CArGome) have identified new SRF target genes. In addition to circular and longitudinal smooth muscle layers, SRF is also expressed in GI mucosa and cancers. In the GI tract, SRF is the central regulator of genes involved in apoptosis, dedifferentiation, proliferation, and migration of cells. Since SRF is the cell phenotypic modulator, it may play an essential role in the development of myopathy, hypertrophy, ulcers, gastric and colon cancers within the GI tract. Given the multi-functional role displayed by SRF in the digestive system, SRF has received more attention emerging as a potential therapeutic target. This review summarizes the findings in SRF research pertaining to the GI tract and provides valuable insight into future directions.