Carotid artery intima-media thickness and plaque score for the risk assessment of stroke subtypes
Carotid artery intima-media thickness and plaque score for the risk assessment of stroke subtypes
复制标题
DOI：
10.1016/s0301-5629(02)00573-2
复制
发表时间：
2002-10-01
影响因子：
2.9
通讯作者：
Matsumoto, M
中科院分区：
文献类型：
--
作者：
Nagai, Y;Kitagawa, K;Matsumoto, M
作为颈动脉粥样硬化严重程度的衡量指标，我们比较了颈总动脉(CCA)内中膜厚度(IMT)和斑块评分(PS)对不同卒中亚型的风险评估。研究对象包括792名非卒中患者和311名卒中患者，其中动脉粥样硬化性脑梗塞(AI)72例，腔隙性脑梗塞(LI)113例，心源性脑梗塞54例，脑出血29例。双侧颈总动脉远端壁测量IMT，并取平均值。将双侧颈动脉斑块的最大厚度相加得到PS。AI和LI患者的IMT和PS均大于非卒中患者(均P<0.05)，但在其他亚型和非卒中患者之间相似。通过受试者工作特征(ROC)曲线分析，这两个指标都区分了AI和LI(均为P<；0.05)的可能性，但不能区分其他亚型。在区分AI时，PS定义的ROC面积(0.80)大于IMT定义的ROC面积(0.68)(p<；0.05)。因此，尽管CCA IMT和PS似乎都有助于AI和LI的风险评估，但PS可能更有效地评估AI的风险。(电子邮件：nagaiy@medone.med.osaka-U.S.ac.jp)(C)2002年世界医学生物学超声联合会。
As measures for the severity of carotid atherosclerosis, we compared common carotid artery (CCA) intima-media thickness (IMT) and plaque score (PS) for risk assessment of respective stroke subtypes. The subjects comprised 792 nonstroke and 311 stroke patients, including 72 with atherothrombotic infarction (AI), 113 with lacunar infarction (LI), 54 with cardioembolic infarction and 29 with cerebral hemorrhage. IMT was bilaterally measured on CCA far walls, and averaged. PS was obtained by summing up the maximum thickness of all plaques in bilateral carotid arteries. Both IMT and PS were greater in AI and LI patients than in nonstroke patients (all p < 0.05), but similar between other subtype and nonstroke patients. By receiver operating characteristic (ROC) curve analyses, both measures discriminated the likelihood for AI and LI (all p < 0.05), but not for other subtypes. When discriminating AI, ROC area defined by PS (0.80) was greater than that defined by IMT (0.68) (p < 0.05). Thus, although both CCA IMT and PS appear to help for risk assessment of AI and LI, risk of AI may be more effectively assessed by PS. (E-mail: nagaiy@medone.med.osaka-u.ac.jp) (C) 2002 World Federation for Ultrasound in Medicine Biology.