From Metabolic Normality to Cardiometabolic Risk Factors in Subjects With Obesity
From Metabolic Normality to Cardiometabolic Risk Factors in Subjects With Obesity
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DOI：
10.1038/oby.2012.69
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发表时间：
2012-10-01
期刊：
影响因子：
6.9
通讯作者：
Golay, Alain
中科院分区：
文献类型：
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作者：
Bobbioni-Harsch, Elisabetta;Pataky, Zoltan;Golay, Alain
本研究的目的是评价基线时代谢正常的超重或肥胖（ow/ob）和正常体重（nbw）受试者中心脏代谢风险因素（如空腹血糖受损、高密度脂蛋白（HDL）-胆固醇降低、血浆甘油三酯或血压升高以及葡萄糖耐量受损）的3年发生率。分析了胰岛素敏感性与心血管疾病（RISC）研究的受试者。我们分析了284名正常体重者和152名肥胖者，他们在基线时没有表现出任何上述的心脏代谢危险因素。在3年时，重新评价了这些参数。超声测量颈总动脉（CCA）内膜中层厚度（IMT）。随访时，一种或多种心脏代谢危险因素的发生率在ow/ob组为57.2%，而在nbw组为31.7%（P < 0.0001）。在调整年龄、性别、绝经状态、生活方式参数、胰岛素敏感性和空腹胰岛素血症后，BMI仍然与一种或多种心脏代谢危险因素的发生显著相关（P = 0.02）。在nbw和ow/ob组中，随访时BMI增加与心脏代谢改变的发生显著相关（P = 0.04）。OW/OB受试者在3年随访时保持代谢正常，但与NBW受试者相比，其心脏代谢状况较差。在ow/ob代谢正常的男性和女性中，随访时颈总动脉内膜中层比nbw厚（男性P = 0.03，女性P = 0.04）。总之，在短期随访中，代谢正常的肥胖受试者心脏代谢危险因素的发生率较高。体重增加与这些因素的发展显着相关，无论是在nbw和ow/ob受试者。
The aim of the study was to evaluate the 3 years incidence of cardiometabolic risk factors, such as impaired fasting glucose, reduced high-density lipoprotein (HDL)-cholesterol, increased plasma triglycerides or blood pressure as well as impaired glucose tolerance in overweight or obese (ow/ob) and normal body weight (nbw) subjects metabolically normal at baseline. Subjects from the Relationship between Insulin Sensitivity and Cardiovascular Disease (RISC) study were analyzed. We analyzed 284 nbw and 152 ow/ob subjects who, at baseline, did not show any of the above-mentioned cardiometabolic risk factors. At 3 years, these parameters were re-evaluated. Intima-media thickness (IMT) of the common carotid artery (CCA) was echographically measured. At follow-up, the incidence of one or more cardiometabolic risk factors was 57.2% in ow/ob vs. 31.7% in nbw (P < 0.0001). After adjustment for age, sex, menopause status, lifestyle parameters, insulin sensitivity, and fasting insulinemia, BMI remained significantly linked to the development of one or more cardiometabolic risk factors (P = 0.02). An increased BMI at follow-up was significantly associated with the development of cardiometabolic alterations, in both nbw and ow/ob groups (P = 0.04). Ow/ob subjects who, at 3 years follow-up, remained metabolically normal, showed a less favourable cardiometabolic profile, when compared to nbw counterparts. In ow/ob metabolically normal males and females, intima-media of the common carotid at follow-up was thicker than in nbw (P = 0.03 for males, P = 0.04 for females). In conclusion, metabolically normal obese subjects show a higher incidence of cardiometabolic risk factors, in a short follow-up period. Weight gain is significantly associated with the development of these factors, in both nbw and ow/ob subjects.