Dynorphin blocks opioid inhibition of macrophage-colony stimulating factor-induced proliferation of bone marrow cells.
Dynorphin blocks opioid inhibition of macrophage-colony stimulating factor-induced proliferation of bone marrow cells.
复制标题
强啡肽可阻断阿片类药物对巨噬细胞集落刺激因子诱导的骨髓细胞增殖的抑制作用。
DOI：
10.1016/0014-2999(91)90278-x
复制
发表时间：
1991
影响因子：
5
通讯作者：
Lee,NM
中科院分区：
文献类型：
--
作者：
Roy,S;Loh,HH;Lee,NM
我们以前报道，吗啡抑制巨噬细胞集落刺激因子（M-CSF）诱导的小鼠骨髓细胞增殖，在体内和体外，以剂量依赖的方式。我们现在报道，强啡肽A-（1-13）或强啡肽A-（1-10）酰胺，虽然在浓度低于0.1 mM时对增殖本身没有影响，但可以剂量依赖性方式阻断吗啡在体内和体外的抑制作用。阿片受体拮抗剂纳洛酮在体内也能阻断吗啡对骨髓细胞增殖的抑制作用，但在体外无此作用。强啡肽A-（1-13）也能够阻断在用吗啡长期处理的动物中观察到的脾重量的急剧减少。因此，强啡肽，它以前已被证明拮抗吗啡镇痛，也能够拮抗吗啡的一些免疫抑制作用。
We previously reported that morphine inhibits macrophage-colony stimulating factor (M-CSF)-induced proliferation of mouse bone marrow cells, both in vivo and in vitro, in a dose-dependent manner. We now report that either dynorphin A-(1–13) or dynorphin A-(1–10) amide, though having no effect on proliferation by themselves at concentrations less than 0.1 mM, can block the inhibitory effect of morphine both in vivo and in vitro, in a dose-dependent manner. The opioid antagonist naloxone can also block morphine's inhibitory effect on bone marrow cell proliferation in vivo, but has no effect in vitro. Dynorphin A-(1–13) was also able to block the dramatic reduction of spleen weight observed in animals chronically treated with morphine. Thus dynorphin, which has previously been shown to antagonize morphine analgesia, is also able to antagonize some of the immunosuppressive effects of morphine.