Breed distribution and history of canine mdr1-1Δ, a pharmacogenetic mutation that marks the emergence of breeds from the collie lineage
Breed distribution and history of canine mdr1-1Δ, a pharmacogenetic mutation that marks the emergence of breeds from the collie lineage
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DOI：
10.1073/pnas.0402374101
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发表时间：
2004-08-10
影响因子：
11.1
通讯作者：
Pedersen, NC
中科院分区：
文献类型：
--
作者：
Neff, MW;Robertson, KR;Pedersen, NC
犬类多药耐药基因mdr1的突变此前曾与牧羊犬血统中的两个品种的药物敏感性有关。我们利用品种系统发展史和药物敏感性报告来调查其他可能存在遗传风险的纯种种群。我们发现，相同的等位基因mdr1-1Delta在另外七个品种中分离，其中包括两个不被认为具有牧羊犬祖先的视野犬。在受影响的品种中保守的突变单倍型表明，等位基因通过血统是相同的。根据品种历史和连锁不平衡的程度，我们得出结论，所有携带MDR1-1 Delta的狗都是在登记品种的遗传隔离(约1873年)之前生活在英国的一只狗的后代。MDR1-1Delta的品种分布和频率在兽医和选择性育种中有应用，而该等位基因的历史记录了从混合的工作牧羊犬群体中出现正式认可的品种。
A mutation in the canine multidrug resistance gene, MDR1, has previously been associated with drug sensitivities in two breeds from the collie lineage. We exploited breed phylogeny and reports of drug sensitivity to survey other purebred populations that might be genetically at risk. We found that the same allele, mdr1-1Delta, segregated in seven additional breeds, including two sighthounds that were not expected to share collie ancestry. A mutant haplotype that was conserved among affected breeds indicated that the allele was identical by descent. Based on breed histories and the extent of linkage disequilibrium, we conclude that all dogs carrying mdr1-1Delta are descendants of a dog that lived in Great Britain before the genetic isolation of breeds by registry (ca. 1873). The breed distribution and frequency of mdr1-1Delta have applications in veterinary medicine and selective breeding, whereas the allele's history recounts the emergence of formally recognized breeds from an admixed population of working sheepdogs.