DCS blood flow index underestimates skeletal muscle perfusion in vivo: rationale and early evidence for the NIRS-DCS perfusion index.
DCS blood flow index underestimates skeletal muscle perfusion in vivo: rationale and early evidence for the NIRS-DCS perfusion index.
复制标题
DCS 血流指数低估了体内骨骼肌灌注：NIRS-DCS 灌注指数的基本原理和早期证据。
DOI：
10.1117/1.jbo.29.2.020501
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发表时间：
2024
影响因子：
3.5
通讯作者：
Nelson,MichaelD
中科院分区：
文献类型：
--
作者：
Bartlett,MilesF;Oneglia,AndrewP;Ricard,MarkD;Siddiqui,Ashfaq;Englund,ErinK;Buckley,ErinM;Hueber,DennisM;Nelson,MichaelD
弥散相关光谱（DCS）可以无创地评估骨骼肌血流，但可能会错误估计肌肉灌注的变化。在生理扰动过程中错误估计肌肉血流量的变化，并介绍了一种新的方法，调整BFI的估计血管舒张的变化。方法我们测量了肌肉BFI的变化，在四头肌和前臂运动使用DCS，后者进行了调整，估计微血管流量面积的变化，然后比较多普勒超声在肱动脉。然后，我们比较了调整后的BFI和动脉自旋标记（ASL）的腓肠肌血流的MRI测量反应性充血和跖屈exercise.ResultsWe观察到的最大努力运动过程中股四头肌BFI几乎没有变化。同样，前臂BFI适度增加，在握力锻炼，但幅度显着低于多普勒超声测量的肱动脉。然而，这种差异得到改善后，调整BFI的估计变化，微血管流量面积。在腓肠肌中也观察到类似的观察时，直接比较调整后的BFI值ASL-MRI.ConclusionsAdjusting BFI的微血管流量面积的估计变化可能会提高DCS估计的肌肉血流量，但需要进一步的研究来验证这些方法前进。
SignificanceDiffuse correlation spectroscopy (DCS) permits non-invasive assessment of skeletal muscle blood flow but may misestimate changes in muscle perfusion.AimWe aimed to highlight recent evidence that DCS blood flow index (BFI) misestimates changes in muscle blood flow during physiological perturbation and to introduce a novel approach that adjusts BFI for estimated changes in vasodilation.ApproachWe measured changes in muscle BFI during quadriceps and forearm exercises using DCS, the latter of which were adjusted for estimated changes in microvascular flow area and then compared to Doppler ultrasound in the brachial artery. Then, we compared adjusted BFI- and arterial spin labeling (ASL) MRI measures of gastrocnemius blood flow during reactive hyperemia and plantar flexion exercise.ResultsWe observed little-to-no change in quadriceps BFI during maximal-effort exercise. Similarly, forearm BFI was modestly increased during handgrip exercise, but the magnitude was significantly lower than measured by Doppler ultrasound in the brachial artery. However, this difference was ameliorated after adjusting BFI for estimated changes in microvascular flow area. Similar observations were also observed in the gastrocnemius when directly comparing the adjusted BFI values to ASL-MRI.ConclusionsAdjusting BFI for estimated changes in microvascular flow area may improve DCS estimates of muscle blood flow, but further study is needed to validate these methods moving forward.