Rational Design of a Porous Supramolecular Peptide Framework (SPF): A Crystalline Tetraproline in the Polyproline II Conformation
Rational Design of a Porous Supramolecular Peptide Framework (SPF): A Crystalline Tetraproline in the Polyproline II Conformation
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DOI：
10.26434/chemrxiv-2021-kxdg9
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发表时间：
2021-12
期刊：
影响因子：
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通讯作者：
Aniello Palma;Dominc F. Brightwell;Giada Truccolo;Kushal Samanta;Elliott J. Fenn;S. Holder;H. Shepherd
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文献类型：
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作者：
Aniello Palma;Dominc F. Brightwell;Giada Truccolo;Kushal Samanta;Elliott J. Fenn;S. Holder;H. Shepherd
在此，我们提出了第一个高分辨率的单晶结构的未官能化的四聚脯氨酸的聚脯氨酸II构象。这种合理设计的寡聚脯氨酸四聚体自组装形成永久多孔的结晶状超分子肽框架（SPF）。热活化，客人列入和热诱导释放的化学客人已被证明为这一新的系统。这一发现提供了一个结论性的洞察到前的模糊构象的短寡脯氨酸，并将允许进一步发展的脯氨酸为基础的肽接头的SPF和金属肽框架的合理设计。
Herein, we present the first high resolution single crystal structure of an unfunctionalized tetrameric proline in the poly-proline II conformation. This rationally designed oligoproline tetramer, self-assembles to form a permanently porous crys-talline supramolecular peptide framework (SPF). Thermal activation, guest inclusion and thermally induced release of chemical guests have been demonstrated for this novel system. This discovery provides a conclusive insight into the pre-viously ambiguous conformation of short oligoprolines and will allow for the further development of proline-based pep-tide linkers in the rational design of SPFs and metal-peptide frameworks.