Impact of abdominal visceral fat, growth hormone, fitness, and insulin on lipids and lipoproteins in older adults.
Impact of abdominal visceral fat, growth hormone, fitness, and insulin on lipids and lipoproteins in older adults.
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腹部内脏脂肪、生长激素、健身和胰岛素对老年人脂质和脂蛋白的影响。
DOI：
10.1053/meta.2003.50007
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
Hartman,MarkL
中科院分区：
文献类型：
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作者：
Weltman,Arthur;Despres,JeanPierre;Clasey,JodyL;Weltman,JudyY;Wideman,Laurie;Kanaley,Jill;Patrie,James;Bergeron,Jean;Thorner,MichaelO;Bouchard,Claude;Hartman,MarkL
本文研究了19名女性(不服用雌激素)和31名男性(男性)60岁以上(年龄66.8岁)腹部内脏脂肪(AVF)与血浆脂质和脂蛋白浓度的关系。此外，还检测了生长激素(GH)释放、健身([VDOT]O2峰值)、胰岛素和葡萄糖浓度(空腹和口服葡萄糖耐量试验的反应)对血脂的影响。受试者被分为低(L)和高(H)AVF(L 130cm2，H[GT]130cm2)，脂肪质量(FM)(高于或低于中位数)，并根据脂肪质量校正AVF。因素方差分析显示，将受试者分为AVF和FM后，极低密度脂蛋白胆固醇、甘油三酯、极低密度脂蛋白胆固醇、载脂蛋白B、载脂蛋白B、载脂蛋白B、胆固醇/高密度脂蛋白、低密度脂蛋白/高密度脂蛋白、载脂蛋白B/高密度脂蛋白、高密度脂蛋白/高密度脂蛋白、载脂蛋白B/A1、高密度脂蛋白/高密度脂蛋白、高密度脂蛋白/高密度脂蛋白、高密度脂蛋白/高密度脂蛋白、高密度脂蛋白/高密度脂蛋白、载脂蛋白A1和低密度脂蛋白/高密度脂蛋白的结果与L(P[lt].05)相似。用F[GT]M也观察到CHOL、LDL、HDL2和HDL2的性别差异。当AVF被纠正为FM时，这些性别差异仍然存在。校正Fm后，H组与L aVF组间极低密度脂蛋白、甘油三酯、极低密度脂蛋白-甘油三酯、载脂蛋白B、载脂蛋白B-低密度脂蛋白、载脂蛋白-B极低密度脂蛋白、载脂蛋白B/A1差异有统计学意义(P<0.05)。F组24小时生长激素浓度(IGHC)与极低密度脂蛋白(VLDL)、极低密度脂蛋白(TG)、极低密度脂蛋白(TG)、极低密度脂蛋白(LDL-TG)、载脂蛋白B(ApoB)、载脂蛋白B(ApoB)、极低密度脂蛋白(VLDL)、载脂蛋白B/高密度脂蛋白(apoB/LDL)、胆固醇/高密度脂蛋白(Chol/HDL)、载脂蛋白B/A1(apoB/A1)呈负相关(P<0.05)。[VDOT]O2峰与胆固醇、低密度脂蛋白、高密度脂蛋白胆固醇、载脂蛋白-B-低密度脂蛋白直接相关，与F的相关性更强。无论男女，空腹胰岛素与血脂和脂蛋白有关。这些数据表明，在老年人中，AVF、FM和经FM校正的AVF水平升高与不利的脂脂蛋白谱相关，并扩大了在AVF升高的年轻男性和女性中报道的类似发现。这些数据也支持先前的发现，即AVF是GH释放的主要决定因素。
We examined the relationship between abdominal visceral fat (AVF) and plasma concentrations of lipids and lipoproteins in 19 females (F) (not on estrogen) and 31 males (M) over the age of 60 (age = 66.8 years). In addition, the effects of growth hormone (GH) release, fitness ([Vdot ]o2peak), insulin, and glucose concentrations (both fasting and in response to an oral glucose tolerance test) on lipids were examined. Subjects were categorized by low (L) and high (H) AVF (L [lt ] 130 cm2, H [gt ] 130 cm2), fat mass (FM) (above or below median value), and AVF corrected for fat mass. Factorial analysis of variance (ANOVA) showed that when subjects were divided by AVF and FM, similar results were observed with H [gt ] L (P [lt ] .05) for very[ndash ]low-density lipoprotein-cholesterol (VLDL-C), triglycerides (TG), VLDL-TG, apolipoprotein (apo)-B, apo-B VLDL, cholesterol (Chol)/high-density lipoprotein (HDL), LDL/HDL, apoB/A1 and L [gt ] H for HDL, HDL2, HDL3, apo A1, and LDL/apo-B LDL. Gender differences were also observed with F [gt ] M for Chol, LDL, HDL, and HDL2. When AVF was corrected for FM, these gender differences were still present. After correcting for FM, differences remained between H and L AVF groups for VLDL, TG, VLDL-TG, apo-B, apo-B LDL, apo-B VLDL, apoB/A1 (P [lt ] .05). Twenty-four hour integrated GH concentration (IGHC) was inversely related to VLDL, TG, VLDL TG, LDL TG, apoB, apoB VLDL, apoB LDL, Chol/HDL, LDL/HDL, and apoB/A1 in F, but not M (P [lt ] .05). [Vdot ]o2peak was directly related to Chol, LDL, HDL3, and apoB LDL with stronger relationships observed in F. Fasting insulin was related to lipids and lipoproteins in both men and women. These data suggest that, in older adults, elevated levels of AVF, FM, and AVF corrected for FM are associated with unfavorable lipid-lipoprotein profiles and extend similar findings reported in younger males and females with elevated AVF. These data also support previous findings indicating that AVF is a primary determinant of GH release.