Signaling by sulfur-containing molecules. Quantitative aspects
Signaling by sulfur-containing molecules. Quantitative aspects
复制标题
DOI：
10.1016/j.abb.2016.09.012
复制
发表时间：
2017-03-01
影响因子：
3.9
通讯作者：
Bounds, Patricia L.
中科院分区：
文献类型：
--
作者：
Koppenol, Willem H.;Bounds, Patricia L.
目前，人们对可能在信号传导中起作用或不起作用的含硫分子感兴趣。我们已经收集了相关的热力学数据，即标准吉布斯生成能和电极电位在pH 7，并使用这些来构建一个弗罗斯特图。文献中没有的热力学数据可以合理的置信度估计。在pH 7时，RSS中心点/RSS-电对的电极电位为+0.68V，比RS中心点、H+/RSH电对的电极电位低0.28V。S-2（中心点-）相对于HSS-和S-2不稳定。通常，除了RSSR之外，多硫化合物对于反硝化是化学上不稳定的，并最终导致形成动力学惰性的Sg（s）。热中性的是RSSR和HS-生成RSS-，而HS-和SNO-以及HS-和RSNO生成HNO-则是不利的。体内SSNO的形成在动力学上是不可能的。(C)2016 Elsevier Inc. All rights reserved.
There is currently interest in sulfur-containing molecules that may or may not play a role in signaling. We have collected relevant thermodynamic data, namely standard Gibbs energies of formation and electrode potentials at pH 7, and used these to construct a Frost diagram. Thermodynamic data not available in the literature could be estimated with reasonable confidence. At pH 7, the electrode potential of the RSS center dot/RSS- couple is +0.68 V, 0.28 V less than that of the RS center dot, H+/RSH couple. S-2(center dot-) is unstable with respect to HSS- and S-2. Generally, polysulfur compounds, with the exception of RSSR, are thermodynamically unstable with respect to disproportionation and ultimately lead to formation of kinetically inert Sg(s). About thermoneutral is the formation of RSS- from RSSR and HS-, but formation of HNO- from HS- and SNO-(,) and from HS- and RSNO, is unfavorable. The formation of SSNO in vivo is kinetically unlikely. (C) 2016 Elsevier Inc. All rights reserved.