On-line compensation for perturbations of a reaching movement is cerebellar dependent: support for the task dependency hypothesis.
On-line compensation for perturbations of a reaching movement is cerebellar dependent: support for the task dependency hypothesis.
复制标题
对到达运动的扰动的在线补偿是小脑依赖性的：支持任务依赖性假设。
DOI：
10.1007/s00221-003-1713-0
复制
发表时间：
2004
影响因子：
2
通讯作者：
Bloedel,JamesR
中科院分区：
文献类型：
--
作者：
Shimansky,Yury;Wang,Jian-Jun;Bauer,RichardA;Bracha,Vlastislav;Bloedel,JamesR
Although the cerebellum has been shown to be critical for the acquisition and retention of adaptive modifications in certain reflex behaviors, this structure’s role in the learning of motor skills required to execute complex voluntary goal-directed movements still is unclear. This study explores this issue by analyzing the effects of inactivating the interposed and dentate cerebellar nuclei on the adaptation required to compensate for an external elastic load applied during a reaching movement. We show that cats with these nuclei inactivated can adapt to predictable perturbations of the forelimb during a goal-directed reach by including a compensatory component in the motor plan prior to movement initiation. In contrast, when comparable compensatory modifications must be triggeredon-linebecause the perturbations are applied in randomized trials (i.e., unpredictably), such adaptive responses cannot be executed or reacquired after the interposed and dentate nuclei are inactivated. These findings provide the first demonstration of the condition-dependent nature of the cerebellum’s contribution to the learning of a specific volitional task.
