Y-chromosomal factor is involved in neonatal lethality in (♀ DDD × ♂DH-Dh/+) F1-Dh/+ male mice
Y-chromosomal factor is involved in neonatal lethality in (♀ DDD × ♂DH-Dh/+) F1-Dh/+ male mice
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Y 染色体因子参与 (♀ DDD × ♂DH-Dh/+) F1-Dh/+ 雄性小鼠的新生儿致死率
DOI：
10.1007/bf02684019
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发表时间：
2002
期刊：
影响因子：
2.5
通讯作者：
K. Sekikawa
中科院分区：
文献类型：
--
作者：
J. Suto;K. Sekikawa
显性半肢畸形（Dh）突变导致小鼠的各种发育异常。大多数-Dh/+男性，DDD女性和DH-Dh/+男性之间的交叉，在新生儿期有致命的异常。这是三个独立基因位点之间协同作用的结果;即，染色体（Chr）1上的Dh等位基因，X Chr连锁位点上的DDD等位基因，以及某些菌株中的Y Chr连锁位点。对来源于小家鼠（Mus musculus musculus（M. M. C57 BL/6 J和BALB/cA的Y Chr对小鼠有致死作用，而C3 H/HeJ的Y Chr对小鼠无致死作用。M. Y肌也是一样。在本研究中，Y Chrs是否来源于mM。M. Aestheticus和M. M.栗可能导致的致死性进行了调查。在AKR/J、DDD、RF/J、SJL/J、SWR/J、TIRANO/Ei和CAST/Ei等7个近交系中，AKR/ J、DDD、SJL/J、SWR/J和TIRANO/Ei的Y Chrs能引起致死性，而RF/J和CAST/Ei的Y Chrs不能引起致死性。DDD菌株的线粒体基因组不太可能导致致死性。X染色体连锁位点不能弥补Y染色体连锁位点的作用。这些结果表明，不是所有的M。M.这两个词都是一样的。
The dominant hemimelia(Dh) mutation causes various developmental abnormalities in mice. Most -Dh/+ males, crosses between DDD females and DH-Dh/+ males, have lethal abnormalities during the neonatal period. This is a consequence of synergism among three independent gene loci; that is, theDh allele on chromosome (Chr) 1, the DDD allele on an X Chr-linked locus, and a Y Chr-linked locus in some strains. With regard to the Y Chr derived fromMus musculus musculus (M. m. musculus), the Y Chrs of C57BL/6J and BALB/cA caused lethality, but the Y Chr of C3H/HeJ did not, suggesting that not allM. m. musculus Y Chrs are the same. In the present study, whether Y Chrs derived fromM. m. domesticus andM. m. castaneus could cause lethality was investigated. Among seven inbred strains, including AKR/J, DDD, RF/J, SJL/J, SWR/J, TIRANO/Ei, and CAST/Ei, Y Chrs of AKR/ J, DDD, SJL/J, SWR/J, and TIRANO/Ei caused lethality, but Y Chrs of RF/J and CAST/Ei did not. It was unlikely that the mitochondrial genome of the DDD strain contributed to the lethality. The X Chr-linked locus could not compensate for the role of the Y Chr-linked locus. These results suggest that not allM. m. domesticus Y Chrs are the same.
Sry 等位基因（Mus 亚属）的 DNA 序列分析表明错误调节是 C57BL/6J-Y(POS) 性逆转的原因，并定义了 SRY 功能单元。
影响因子：
3.3
作者：
Albrecht,KH;Eicher,EM
通讯作者：
Eicher,EM
影响因子：
4.4
作者：
Carlisle, C;Winking, H;Nagamine, CM
通讯作者：
Nagamine, CM