Hypnotic medication use among inpatients with schizophrenia and major depressive disorder: results of a nationwide study
Hypnotic medication use among inpatients with schizophrenia and major depressive disorder: results of a nationwide study
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DOI：
10.1016/j.sleep.2021.11.005
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发表时间：
2022-01-01
期刊：
影响因子：
4.8
通讯作者：
Hashimoto，Ryota
中科院分区：
文献类型：
--
作者：
Furihata，Ryuji;Otsuki，Rei;Hashimoto，Ryota
研究目的 调查精神分裂症和重度抑郁症住院患者服用催眠药物的比例，以及此类药物与使用其他抗精神病药物之间的关联。 方法这是一项全国性的横断面研究，是“精神科治疗传播和教育指南的有效性”(EGUIDE) 项目的一部分。分析了 2146 名精神分裂症住院患者和 1031 名重度抑郁症住院患者的数据。记录所有精神药物的种类和剂量，并分析出院时的数据。使用多变量logistic回归分析评估使用催眠药物和其他抗精神病药物之间的关联。结果服用任何一种或两种或两种以上催眠药物的精神分裂症患者比例分别为56.5%和17.9%，重度抑郁症患者的相应比例分别为64.9%和23.1%。在精神分裂症患者中，多变量逻辑回归分析显示，两种或多种抗精神病药、抗胆碱能药、抗焦虑药和情绪稳定剂/抗癫痫药与任何催眠药的使用呈正相关。在重度抑郁症患者中，多变量逻辑回归分析显示，两种或多种抗抑郁药、两种或多种抗精神病药、抗焦虑药和心境稳定剂/抗癫痫药与任何催眠药的使用呈正相关。结论发现，精神障碍住院患者服用催眠药的频率很高。两种或多种主要抗精神病药物的处方通常与使用催眠药物治疗精神分裂症和重度抑郁症有关。
Study objectivesTo investigate the proportion of inpatients with schizophrenia and major depressive disorder prescribed hypnotic medication, and the association between such medication and the use of other antipsychotic agents.MethodsThis was a nationwide cross-sectional study performed as part of the ‘Effectiveness of Guidelines for Dissemination and Education in Psychiatric Treatment’ (EGUIDE) project. Data from 2146 inpatients with schizophrenia and 1031 inpatients with major depressive disorder were analyzed. All types and dosages of psychotropic drugs were recorded and the data at the time of discharge were analyzed. Associations between the use of hypnotic medication and other antipsychotic agents were evaluated using multivariate logistic regression analyses.ResultsThe proportions of schizophrenia patients who were prescribed any and two or more hypnotic agents were 56.5% and 17.9%, respectively, and the corresponding proportions for patients with major depressive disorder were 64.9% and 23.1%, respectively. In schizophrenia patients, multivariate logistic regression analyses showed that two or more antipsychotics, anticholinergic drugs, anxiolytics, and mood stabilizers/antiepileptic drugs were positively associated with the use of any hypnotic agent. In patients with major depressive disorder, multivariate logistic regression analyses revealed that two or more antidepressants, two or more antipsychotics, anxiolytics, and mood stabilizers/antiepileptic drugs were positively associated with the use of any hypnotic agent.ConclusionsPrescription of hypnotic agents was found to be highly frequent among inpatients with psychiatric disorders. Prescription of two or more main antipsychotic agents was commonly associated with the use of hypnotic medication for both schizophrenia and major depressive disorder.