Within-night variation in respiratory effort preceding apnea termination and EEG delta power in sleep apnea
Within-night variation in respiratory effort preceding apnea termination and EEG delta power in sleep apnea
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DOI：
10.1152/jappl.1998.85.4.1434
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发表时间：
1998-10-01
影响因子：
3.3
通讯作者：
Khoo, MCK
中科院分区：
文献类型：
--
作者：
Berry, RB;Asyali, MA;Khoo, MCK
我们研究了9例重度阻塞性睡眠呼吸暂停患者在呼吸暂停终止前最大食管压力偏移（DPmax）的夜间变异性，作为觉醒阈值的指标，并研究了每30 s的平均脑电图（EEG）δ功率作为睡眠周期时间的指标。通过确定Δ功率和DPmax的功率谱密度以及通过互相关确定的它们的关系，分析了它们的时间变化的周期性。DPmax和Δ功率周期性地变化，并且与主要周期性同相（功率谱密度的主峰）为117.6 +/- 8.8（SE）min。DPmax值与Δ功率值之间的相关性显著（P < 0.001）（平均r = 0.47 +/-0.03），DPmax与Δ功率在其主频处的相关性高。在非快速眼动睡眠周期内，DPmax和Δ功率增加，平均在周期中期或之后达到峰值。这些发现表明，阻塞性睡眠呼吸暂停患者的气道阻塞唤醒阈值在夜间周期性变化，与睡眠的潜在周期同步。
We studied the within-night variability of the maximum esophageal pressure deflection before apnea termination (DPmax) in nine patients with severe obstructive sleep apnea as an index of the arousal threshold and the mean electroencephalogram (EEG) delta power for each 30 s as an index of the timing of sleep cycles. Periodicity in the time variation of delta power and DPmax was analyzed by determining their power spectral density and their relationship determined by cross correlation. DPmax and delta power varied cyclically and in phase with a major periodicity (major peak in power spectral density) of 117.6 +/- 8.8 (SE) min. The correlation between the values of DPmax and delta power was significant (P < 0.001) in each subject (mean r = 0.47 +/- 0.03), and the coherence between DPmax and delta power at their dominant frequency was high. Within cycles of non-rapid-eye-movement sleep, DPmax and delta power increased, reaching peak values on average at or after midcycle. These findings suggest that the arousal threshold to airway occlusion in patients with obstructive sleep apnea varies cyclically during the night synchronous to the underlying cycles of sleep.